{"id":"W3004961655","doi":"10.1523/eneuro.0422-19.2020","title":"Proportional Downscaling of Glutamatergic Release Sites by the General Anesthetic Propofol at<i>Drosophila</i>Motor Nerve Terminals","year":2020,"lang":"en","type":"article","venue":"eNeuro","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto","funders":"National Health and Medical Research Council; Queensland Brain Institute; Medical Research Council; Australian Research Council; Griffith University","keywords":"Propofol; Glutamatergic; Excitatory postsynaptic potential; Glutamate receptor; Neuroscience; Anesthetic; Neurotransmission; Inhibitory postsynaptic potential; Biology; Neurotransmitter; Drosophila melanogaster; Active zone; Pharmacology; Synaptic vesicle; Anesthesia; Medicine; Central nervous system; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167065,0.0002938734,0.0002506511,0.0001059042,0.0001241086,0.0003363448,0.0003101974,0.0003080792,0.001005549],"category_scores_gemma":[0.0001818932,0.000156495,0.0002519836,0.0000611851,0.0002480645,0.0002948638,0.0002522021,0.0006863726,0.0002394244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003931698,"about_ca_system_score_gemma":0.0001542763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009956567,"about_ca_topic_score_gemma":0.001320849,"domain_scores_codex":[0.9998478,0.00001556524,0.0000214327,0.00004045779,0.00004202133,0.00003261421],"domain_scores_gemma":[0.9998063,0.00003278793,0.00008335636,0.00001941028,0.00002254528,0.00003568327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004949886,0.00000729527,0.0001411754,0.00002408042,0.00000330171,0.0000196043,0.000005868811,0.00002672449,0.9992011,0.0000329258,0.00001293623,0.0004754639],"study_design_scores_gemma":[0.00001584947,0.0002396297,0.01708265,0.000008755684,0.00001698885,0.000161535,0.00003117316,0.001069109,0.9807553,0.00002775117,0.0005854667,0.00000575184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965447,0.00050489,0.001669567,0.00006307055,0.00001524512,0.00001761312,0.0001763212,0.00004877248,0.0009598648],"genre_scores_gemma":[0.9957284,0.0005290225,0.002363799,0.00009355294,0.000007816824,0.00003684957,0.0001968361,0.00002682032,0.001016873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005549,"threshold_uncertainty_score":0.003363907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03725979813444712,"score_gpt":0.2840202455557017,"score_spread":0.2467604474212545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}