{"id":"W3005041247","doi":"10.1016/j.jagp.2020.01.007","title":"Pharmacogenetic Implications for Antidepressant Pharmacotherapy in Late-Life Depression: A Systematic Review of the Literature for Response, Pharmacokinetics and Adverse Drug Reactions","year":2020,"lang":"en","type":"review","venue":"American Journal of Geriatric Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Toronto; Centre for Addiction and Mental Health","funders":"McDonnell Center for Systems Neuroscience; National Institutes of Health; Patient-Centered Outcomes Research Institute; H. Lundbeck A/S; Centre for Addiction and Mental Health; Canadian Institutes of Health Research; Centre for Addiction and Mental Health Foundation; Fondation Brain Canada; Washington State University; University of Pittsburgh; Takeda Pharmaceuticals U.S.A.; Takeda Pharmaceutical Company; Eli Lilly and Company; Foundation for the National Institutes of Health","keywords":"Antidepressant; Pharmacogenetics; Pharmacotherapy; Depression (economics); Pharmacokinetics; Medicine; Adverse effect; Drug; Pharmacology; Intensive care medicine; Psychiatry; Biology; Genotype; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001014997,0.0005526351,0.003723558,0.0005166429,0.000104403,0.00001935545,0.0005100541,0.0001143536,0.00001085069],"category_scores_gemma":[0.0006268746,0.0003294142,0.001504942,0.00157595,0.0001260992,0.00009404145,0.00006595661,0.0006371844,6.375762e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001196993,"about_ca_system_score_gemma":0.001390034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001968257,"about_ca_topic_score_gemma":2.770923e-7,"domain_scores_codex":[0.9953631,0.0009083354,0.002614146,0.0004461967,0.0003675591,0.0003006779],"domain_scores_gemma":[0.9923677,0.001231908,0.005091633,0.000585951,0.0003797082,0.0003431336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001909111,0.000515828,0.0005508361,0.9230098,0.001641416,0.00001027369,0.000157285,0.000005668458,0.0002488326,0.000003613472,0.008073006,0.06387435],"study_design_scores_gemma":[0.005320283,0.0006134202,0.0005246042,0.7717887,0.02370025,0.001014913,0.00005791632,0.00001779178,0.00002553505,0.00003479369,0.196518,0.0003838192],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007903244,0.9861126,0.0001216474,0.00466844,0.0008327148,0.007019857,0.0004303667,0.00001700298,0.000007038609],"genre_scores_gemma":[0.00060935,0.9929199,0.00411776,0.001038754,0.0004899648,0.0006240624,0.00002620283,0.0001112513,0.0000627734],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.188445,"threshold_uncertainty_score":0.9999158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791070991397585,"score_gpt":0.3614502489798912,"score_spread":0.3435395390659153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}