{"id":"W3005048641","doi":"10.1128/mbio.03202-19","title":"Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; Hospital for Sick Children; University of Toronto; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Canada Research Chairs; Government of Canada; Burroughs Wellcome Fund","keywords":"Conidiation; Aspergillus fumigatus; Virulence; Biology; Microbiology; Downregulation and upregulation; Gliotoxin; Virulence factor; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001019522,0.00007394669,0.0001598239,0.000007765005,0.00006613177,0.000005560723,0.00006733371,0.00006404168,0.000118977],"category_scores_gemma":[0.0003419794,0.00005110718,0.0000827168,0.0002177268,0.00008763576,0.00008412974,0.0000267673,0.0001127993,0.00001852452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004388198,"about_ca_system_score_gemma":0.0001021524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006324078,"about_ca_topic_score_gemma":0.000009328436,"domain_scores_codex":[0.9992092,0.00004435043,0.0002168907,0.0001859837,0.0002297699,0.0001137797],"domain_scores_gemma":[0.9994922,0.00002942229,0.0001000148,0.0002375567,0.00009578201,0.00004497614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002679128,0.00006461342,0.1095376,0.0001814948,0.00002961851,0.000003572579,0.002843094,0.00007302597,0.8805006,0.001740875,0.0007941157,0.003963467],"study_design_scores_gemma":[0.0004777664,0.0001283705,0.6015119,0.00009329735,0.00003340039,0.000001273203,0.0003382532,0.001162703,0.3943031,0.0002801888,0.001594294,0.00007545714],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937533,0.0003539116,0.000547517,0.002653329,0.000120684,0.0002457011,0.00001206064,0.00003324402,0.002280278],"genre_scores_gemma":[0.9986321,0.00002199775,0.0003168031,0.0006946898,0.00009663936,0.00000253573,0.00001471069,0.000007751902,0.0002128244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4919743,"threshold_uncertainty_score":0.208409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02735419744198047,"score_gpt":0.2524518998420246,"score_spread":0.2250977024000441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}