{"id":"W3005048641","doi":"10.1128/mbio.03202-19","title":"Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; Hospital for Sick Children; University of Toronto; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Canada Research Chairs; Government of Canada; Burroughs Wellcome Fund","keywords":"Conidiation; Aspergillus fumigatus; Virulence; Biology; Microbiology; Downregulation and upregulation; Gliotoxin; Virulence factor; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009928802,0.0003751477,0.0001907444,0.0001434078,0.0001180705,0.0003391739,0.0001553853,0.0002203253,0.0008701411],"category_scores_gemma":[0.00006857867,0.00006521839,0.0001158647,0.00008212566,0.0001868312,0.0001009171,0.0001508331,0.0005262766,0.0002049928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115172,"about_ca_system_score_gemma":0.0002526926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007665129,"about_ca_topic_score_gemma":0.001916913,"domain_scores_codex":[0.9999061,0.00001611313,0.000006245265,0.00001652924,0.0000229047,0.00003223735],"domain_scores_gemma":[0.9999553,0.000005852966,0.00001496566,0.000004025513,0.000005787602,0.00001399321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074095,0.00005119171,0.000179408,0.00003437439,0.000004594604,0.00003585939,0.00001141463,0.0001050253,0.9969934,0.0001431394,0.00007646874,0.002257553],"study_design_scores_gemma":[0.00005093701,0.001251727,0.009403801,0.00002840197,0.00003578695,0.000287909,0.0001008042,0.001913466,0.9781806,0.0001687863,0.00856941,0.00000831175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892847,0.003196536,0.003455848,0.0002690355,0.00006836307,0.00006630907,0.0003838947,0.0001385927,0.003136595],"genre_scores_gemma":[0.9953018,0.001254158,0.001244006,0.00007074316,0.000006873897,0.00002838284,0.0001787173,0.000009371039,0.001905849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008701411,"threshold_uncertainty_score":0.002910912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02735419744198047,"score_gpt":0.2524518998420246,"score_spread":0.2250977024000441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}