{"id":"W3005070954","doi":"10.1097/hs9.0000000000000319","title":"The Pediatric Acute Leukemia Fusion Oncogene ETO2‐GLIS2 Increases Self‐Renewal and Alters Differentiation in a Human Induced Pluripotent Stem Cells‐Derived Model","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National Du Cancer; Fondation pour la Recherche Médicale; Cancéropôle Ile de France; Agence Nationale de la Recherche; CNIB","keywords":"Induced pluripotent stem cell; Stem cell; Cell biology; Oncogene; Cancer research; Leukemia; Biology; Embryonic stem cell; Neuroscience; Immunology; Apoptosis; Cell cycle; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009999681,0.0001818852,0.0001467725,0.00003222163,0.0001386365,0.00003779223,0.0001421436,0.0001726526,0.00001324218],"category_scores_gemma":[0.000006351069,0.0001422964,0.00006154301,0.00008777291,0.00001940305,0.00001075782,0.0001599353,0.0001137298,0.000006435377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006523335,"about_ca_system_score_gemma":0.0001094511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008901367,"about_ca_topic_score_gemma":0.000144933,"domain_scores_codex":[0.9989249,0.00008044169,0.0002533164,0.0003514289,0.0001663549,0.0002235564],"domain_scores_gemma":[0.9994345,0.00001217857,0.0001307583,0.0002933747,0.00004704267,0.00008217461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006018651,0.00005258729,0.003669321,0.00002420293,0.00002569067,0.000001364956,0.00006874329,0.0001791355,0.9950734,0.00004112825,0.0002085221,0.0005957666],"study_design_scores_gemma":[0.001511107,0.0002526612,0.001225346,0.00001974536,0.00004370545,0.000005361489,0.0002244396,0.004923293,0.9912217,0.00007390263,0.0002258658,0.000272883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984669,0.0006372836,0.0001099298,0.00004326705,0.0001090207,0.0004190848,0.00000922588,0.00002238024,0.0001829107],"genre_scores_gemma":[0.9981725,0.0008608908,0.0001549367,0.00007964051,0.0001268733,0.00003558535,0.00006403009,0.0000233285,0.000482227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004744157,"threshold_uncertainty_score":0.5802677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007684411805674912,"score_gpt":0.2162401684229523,"score_spread":0.2085557566172773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}