{"id":"W3005070954","doi":"10.1097/hs9.0000000000000319","title":"The Pediatric Acute Leukemia Fusion Oncogene ETO2‐GLIS2 Increases Self‐Renewal and Alters Differentiation in a Human Induced Pluripotent Stem Cells‐Derived Model","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National Du Cancer; Fondation pour la Recherche Médicale; Cancéropôle Ile de France; Agence Nationale de la Recherche; CNIB","keywords":"Induced pluripotent stem cell; Stem cell; Cell biology; Oncogene; Cancer research; Leukemia; Biology; Embryonic stem cell; Neuroscience; Immunology; Apoptosis; Cell cycle; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001919974,0.0002098861,0.0001580002,0.0002747744,0.0001662094,0.0003022829,0.000236118,0.0002589681,0.00266283],"category_scores_gemma":[0.00008527767,0.0001258508,0.0002098619,0.0002655924,0.0001851237,0.0001841856,0.0001700557,0.0005855731,0.0003622332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004072927,"about_ca_system_score_gemma":0.0002976694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001556253,"about_ca_topic_score_gemma":0.002957302,"domain_scores_codex":[0.9998337,0.00002123185,0.00002128387,0.00003127043,0.00006091342,0.00003148439],"domain_scores_gemma":[0.9999216,0.00002058768,0.00002128488,0.000009862058,0.000005561662,0.0000210566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005466542,0.0001459377,0.0006717194,0.00004716768,0.0000187433,0.0001703349,0.00004390151,0.0006456093,0.9926495,0.001106571,0.0007044512,0.003249343],"study_design_scores_gemma":[0.00008511101,0.0003480919,0.004632399,0.000007142341,0.00003194937,0.0002892338,0.00005645843,0.002467405,0.9839298,0.0001145948,0.008032201,0.0000056146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890624,0.0006194717,0.003153607,0.0002103325,0.0000463314,0.0000649445,0.003290046,0.0001337744,0.003419179],"genre_scores_gemma":[0.988675,0.0008379072,0.002130026,0.00007136903,0.000006505141,0.00006722139,0.002660017,0.0000302041,0.005521658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00266283,"threshold_uncertainty_score":0.008908093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007684411805674912,"score_gpt":0.2162401684229523,"score_spread":0.2085557566172773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}