{"id":"W3005112620","doi":"10.1016/j.bpj.2019.11.320","title":"Interplay Between Membrane Curvature and Conformational States in ABC Transporters","year":2020,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Agence Nationale de la Recherche","keywords":"ATP-binding cassette transporter; Lipid bilayer; Biophysics; Transmembrane protein; Membrane curvature; Transporter; Molecular dynamics; Transmembrane domain; Chemistry; Transport protein; Curvature; Protein structure; Cyclic nucleotide-binding domain; Biochemistry; Biology; Membrane; Nucleotide; Receptor; Geometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005702527,0.0002033653,0.0003523325,0.0002501639,0.000354567,0.001059911,0.0002367702,0.0005011141,0.001195037],"category_scores_gemma":[0.001231145,0.0002571692,0.0002333691,0.0001578331,0.0006810027,0.001137969,0.0005504789,0.0005348035,0.0002116552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003825717,"about_ca_system_score_gemma":0.0001928032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002948205,"about_ca_topic_score_gemma":0.0003888199,"domain_scores_codex":[0.9997786,0.0000906686,0.00001219024,0.00002905836,0.00004124778,0.00004831054],"domain_scores_gemma":[0.9995122,0.0002137317,0.00009841549,0.00003349383,0.00006070741,0.00008153937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001474461,0.0001163305,0.0121819,0.0001720809,0.00008027807,0.0006678751,0.0004428515,0.01234172,0.9400634,0.01730778,0.0004251201,0.01472623],"study_design_scores_gemma":[0.0001746918,0.001292463,0.1668102,0.0001088995,0.0001595669,0.002402725,0.0018386,0.3091781,0.4526468,0.06007499,0.004820021,0.0004930324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939594,0.0008013027,0.003460901,0.0004898412,0.00002128288,0.000005421378,0.00003390127,0.00003062423,0.001197269],"genre_scores_gemma":[0.9994691,0.0001893548,0.0002096493,0.00002461065,0.00000508306,0.000001426675,0.00001434819,0.000004784721,0.00008163427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195037,"threshold_uncertainty_score":0.003997803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01244647716051136,"score_gpt":0.2621108271382387,"score_spread":0.2496643499777273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}