{"id":"W3005127469","doi":"10.1186/s13059-020-1926-6","title":"Eleven grand challenges in single-cell data science","year":2020,"lang":"en","type":"review","venue":"Genome biology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1429,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Saint Vincent University; University of British Columbia; BC Cancer Agency","funders":"Institute of Genetics; National Cancer Institute; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; Cancer Research UK Cambridge Institute, University of Cambridge; Helmholtz Zentrum München; BC Cancer Agency; National Health and Medical Research Council; Engineering and Physical Sciences Research Council; Medical Research Council; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Oncode Institute; BC Cancer Foundation; Wageningen University and Research; Cancer Research UK; Lorentz Center; Terry Fox Research Institute; I.M. Sechenov First Moscow State Medical University; Alan Turing Institute; Swiss Institute of Bioinformatics; Universität Zürich; Klaus Tschira Stiftung; Cycle for Survival; Radboud Universitair Medisch Centrum; Universitair Medisch Centrum Groningen; Leids Universitair Medisch Centrum; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Eidgenössische Technische Hochschule Zürich; Bundesministerium für Bildung und Forschung; Universität des Saarlandes; Institute for Research in Biomedicine; Technische Universiteit Delft; Universiteit Utrecht; Rijksuniversiteit Groningen; Deutsche Krebshilfe; SystemsX.ch; Universiteit Leiden; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Radboud Universiteit; Barcelona Institute of Science and Technology; Chan Zuckerberg Initiative; European Molecular Biology Laboratory; Deutsches Krebsforschungszentrum; Universiteit van Amsterdam; Georgia State University; Silicon Valley Community Foundation; Princeton University; Johns Hopkins University; Broad Institute; Universität Duisburg-Essen; University of Connecticut; University of Edinburgh; National Science Foundation; Massachusetts General Hospital; Imperial College London","keywords":"Compendium; Data science; Biology; Field (mathematics); Computer science; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1894186275458333,"score_gpt":0.3282440591390233,"score_spread":0.1388254315931901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}