{"id":"W3005131339","doi":"10.1101/2020.02.08.940296","title":"Genetic variants drive altered epigenetic regulation of endotoxin tolerance in BTBR macrophages","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health","funders":"Intellectual and Developmental Disabilities Research Center; University of California, Davis; National Institutes of Health; National Alliance for Research on Schizophrenia and Depression","keywords":"Chromatin; Epigenetics; Innate immune system; Immune system; Lipopolysaccharide; Biology; Ovalbumin; Phenotype; Immunology; Enhancer; Cell biology; Neuroscience; Gene; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002500875,0.0002990399,0.0002604115,0.0004209539,0.0002189434,0.0002925578,0.0002471051,0.0005136409,0.003299344],"category_scores_gemma":[0.0003023418,0.0002313531,0.0003956421,0.0001930857,0.0003769407,0.0001278856,0.0004448025,0.000830422,0.0007531213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024365,"about_ca_system_score_gemma":0.0001441481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008417616,"about_ca_topic_score_gemma":0.001473628,"domain_scores_codex":[0.9995172,0.00006374461,0.00005113794,0.000157783,0.0001246807,0.0000855632],"domain_scores_gemma":[0.9995661,0.00004589099,0.0002041936,0.00004464592,0.00004440787,0.00009459125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008798204,0.00001126897,0.000404884,0.00001339731,0.000004515306,0.00005660706,0.00001406192,0.00002135058,0.9990546,0.00003654648,0.0000256773,0.0002690533],"study_design_scores_gemma":[0.0001370374,0.001095411,0.164615,0.00008090158,0.0001039531,0.00336808,0.0005076217,0.001924397,0.821348,0.0004353532,0.006332902,0.00005130548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941198,0.000466854,0.003049235,0.0001181356,0.00003546408,0.00001983391,0.001493641,0.0001073089,0.0005897894],"genre_scores_gemma":[0.9948718,0.0002638958,0.001501626,0.0001494191,0.00001172231,0.00004637405,0.001060966,0.00009128619,0.002002933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003299344,"threshold_uncertainty_score":0.01103747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120553320256829,"score_gpt":0.2275133315805346,"score_spread":0.2154579995548517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}