{"id":"W3005142225","doi":"10.1097/qad.0000000000002488","title":"TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells","year":2020,"lang":"en","type":"article","venue":"AIDS","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université Laval; Université de Montréal; Hôpital Maisonneuve-Rosemont; Centre hospitalier de l'Université Laval; Institut National de Santé Publique du Québec","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse","keywords":"TIGIT; Immunology; Biology; Cytotoxic T cell; Population; Natural killer cell; Downregulation and upregulation; Cancer research; Immune system; CD8; Cell biology; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001085179,0.0003060143,0.0002538007,0.0005171795,0.0002082727,0.000496289,0.0002192906,0.0003403179,0.002429579],"category_scores_gemma":[0.0002234937,0.000154384,0.0001899179,0.0003441666,0.000233255,0.0001711453,0.000244562,0.0003276443,0.0004082244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002809056,"about_ca_system_score_gemma":0.0001070779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002803671,"about_ca_topic_score_gemma":0.0002056506,"domain_scores_codex":[0.9998142,0.00001612537,0.0000120926,0.00005768418,0.000043992,0.00005596085],"domain_scores_gemma":[0.9998916,0.00001774466,0.00004041032,0.0000120937,0.00001551512,0.00002259495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002927616,0.00001926598,0.005816688,0.00004245168,0.000007253753,0.0002031454,0.0000420219,0.00002633744,0.991318,0.00003475203,0.00003115779,0.00216621],"study_design_scores_gemma":[0.00005900447,0.001525818,0.3845006,0.00003357977,0.000107381,0.006771337,0.0003723703,0.0007486404,0.6002215,0.0001860234,0.005455031,0.00001876749],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997136,0.001363594,0.0003931872,0.00002562224,0.000007593593,0.00001882426,0.0002323727,0.00003064517,0.0007921612],"genre_scores_gemma":[0.9971542,0.0005073401,0.000892014,0.00003582928,0.00002163595,0.00003081489,0.0005432884,0.00001008456,0.0008046391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002429579,"threshold_uncertainty_score":0.008127749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006967011041877139,"score_gpt":0.1853813638755194,"score_spread":0.1784143528336422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}