{"id":"W3005142225","doi":"10.1097/qad.0000000000002488","title":"TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells","year":2020,"lang":"en","type":"article","venue":"AIDS","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université Laval; Université de Montréal; Hôpital Maisonneuve-Rosemont; Centre hospitalier de l'Université Laval; Institut National de Santé Publique du Québec","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse","keywords":"TIGIT; Immunology; Biology; Cytotoxic T cell; Population; Natural killer cell; Downregulation and upregulation; Cancer research; Immune system; CD8; Cell biology; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00004239697,0.0001252458,0.0001664425,0.00005032632,0.00007782943,0.00001190868,0.00002803948,0.000206758,0.001505101],"category_scores_gemma":[0.00001514537,0.0001103677,0.00004584432,0.0001016551,0.0001059864,0.0001560711,0.00003992347,0.0002879721,0.0001309949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001358128,"about_ca_system_score_gemma":0.00001071328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005984207,"about_ca_topic_score_gemma":9.726693e-7,"domain_scores_codex":[0.9994082,0.00006799956,0.0001670753,0.0002122099,0.00002784651,0.0001166924],"domain_scores_gemma":[0.9997063,0.00004472346,0.0000857106,0.00007203195,0.00007101745,0.00002019925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000681042,0.00002728121,0.001863032,0.00001495474,0.0001513417,3.238108e-7,0.0003067818,0.000001705856,0.6207001,0.0001013216,0.3750879,0.001064259],"study_design_scores_gemma":[0.002443902,0.0009018513,0.03073642,0.00003914642,0.0001109702,0.00006591749,0.0002400919,0.0002202799,0.5416188,0.00004445329,0.4232924,0.000285814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896659,0.003905567,0.0004623192,0.0009828438,0.003780473,0.0001825811,0.00003245115,0.00007052379,0.0009173109],"genre_scores_gemma":[0.9829098,0.0001460886,0.00003601185,0.0008703182,0.00002602365,0.0000040768,0.0002904317,0.000009776801,0.0157075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07908131,"threshold_uncertainty_score":0.9994076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006967011041877139,"score_gpt":0.1853813638755194,"score_spread":0.1784143528336422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}