{"id":"W3005155748","doi":"10.1158/2159-8290.cd-19-1265","title":"Pan-Cancer Efficacy of Vemurafenib in <i>BRAF</i> V600-Mutant Non-Melanoma Cancers","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Cancer Institute; National Institutes of Health; Roche","keywords":"Vemurafenib; Melanoma; Cancer research; Cancer; Mutant; Medicine; Mutation; Metastatic melanoma; Oncology; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000684727,0.0001683745,0.000582224,0.0001268535,0.0001361161,0.0005194972,0.0001571492,0.0002876162,0.001377246],"category_scores_gemma":[0.0005087228,0.00007940148,0.0003111565,0.0001474162,0.0001626227,0.0002622536,0.000187685,0.0007751613,0.000161883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005028589,"about_ca_system_score_gemma":0.0002329028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004345392,"about_ca_topic_score_gemma":0.002816854,"domain_scores_codex":[0.9998457,0.00007099683,0.0000105867,0.00002669189,0.00002391346,0.00002193706],"domain_scores_gemma":[0.9997659,0.00008733353,0.00004196887,0.00002110653,0.00004133373,0.00004232011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03168831,0.002559106,0.02443109,0.001623115,0.0007720098,0.0008869029,0.0002034705,0.001578772,0.3068293,0.001661208,0.04227938,0.5854875],"study_design_scores_gemma":[0.014212,0.1181137,0.3664668,0.0005574013,0.002149079,0.009360948,0.0008523723,0.00689801,0.2642422,0.003959734,0.2130437,0.0001440701],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9426116,0.04267714,0.0009507446,0.006475747,0.0008254573,0.0001313723,0.000686675,0.0001141455,0.005527172],"genre_scores_gemma":[0.9855257,0.0088503,0.0006395637,0.001574936,0.0004189292,0.00006505966,0.0004200203,0.00002447182,0.002480978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377246,"threshold_uncertainty_score":0.004607379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475354711694065,"score_gpt":0.2547850052725076,"score_spread":0.240031458155567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}