{"id":"W3005156010","doi":"10.1200/jco.2020.38.4_suppl.tps261","title":"NRG-GI005 (COBRA): Phase II/III study of circulating tumor DNA as a predictive biomarker in adjuvant chemotherapy in patients with stage II colon cancer.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health","keywords":"Medicine; Oncology; Internal medicine; FOLFOX; Colorectal cancer; Clinical endpoint; Chemotherapy; Adjuvant; Oxaliplatin; Stage (stratigraphy); Biomarker; Prospective cohort study; Cancer; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003615869,0.002016306,0.001869271,0.0006208107,0.0003846954,0.001173544,0.001965055,0.00236808,0.004560222],"category_scores_gemma":[0.002017684,0.0007954214,0.001224067,0.0008267321,0.001643807,0.0008242253,0.0006952964,0.003596551,0.001810121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00160228,"about_ca_system_score_gemma":0.003173149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002780237,"about_ca_topic_score_gemma":0.008248575,"domain_scores_codex":[0.9988819,0.0007187622,0.00003118161,0.0001341967,0.0001010252,0.0001330406],"domain_scores_gemma":[0.9984704,0.0002813425,0.0004042832,0.0001584578,0.00008700378,0.0005985302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8305544,0.04525853,0.01485097,0.0009288332,0.0009172453,0.0001730588,0.0002115884,0.003357415,0.01642319,0.0001997765,0.005895777,0.08122939],"study_design_scores_gemma":[0.6104428,0.3680125,0.0145399,0.00007493493,0.0005480462,0.0002213884,0.00005443377,0.001570121,0.002029412,0.0001323626,0.00233793,0.00003626437],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984772,0.004374077,0.0008165467,0.001557942,0.0001439551,0.003577319,0.002188296,0.0003192441,0.002250654],"genre_scores_gemma":[0.9762908,0.002942255,0.003670638,0.002225739,0.0002002743,0.004995112,0.005587372,0.00008148691,0.00400623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004560222,"threshold_uncertainty_score":0.01912278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04848393316326147,"score_gpt":0.4062087298726107,"score_spread":0.3577247967093492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}