{"id":"W3005212621","doi":"10.1038/s41422-020-0282-0","title":"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro","year":2020,"lang":"en","type":"letter","venue":"Cell Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7384,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wuhan National Biosafety Laboratory; National Natural Science Foundation of China","keywords":"Lopinavir; Ribavirin; Favipiravir; Virology; Chloroquine; Nitazoxanide; Antiviral drug; Middle East respiratory syndrome coronavirus; Biology; Pneumonia; Middle East respiratory syndrome; Coronavirus; Betacoronavirus; Medicine; Immunology; Virus; Coronavirus disease 2019 (COVID-19); Viral load; Internal medicine; Disease; Hepatitis C virus; Infectious disease (medical specialty); Malaria","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002786166,0.000774559,0.0007151987,0.0003175699,0.0002749662,0.0004937262,0.0005338038,0.0003792462,0.005498578],"category_scores_gemma":[0.0002990901,0.0002524981,0.0005215388,0.0001903659,0.0001790089,0.0002994553,0.0002990368,0.001287978,0.001807827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006456422,"about_ca_system_score_gemma":0.0008857057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005469677,"about_ca_topic_score_gemma":0.01815342,"domain_scores_codex":[0.9997856,0.000050373,0.00002435998,0.0000316117,0.00004593903,0.00006217958],"domain_scores_gemma":[0.9998846,0.00002653761,0.00001834464,0.00001378542,0.00002937993,0.00002735777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01296191,0.006149404,0.002998471,0.002357708,0.0003389455,0.0007682765,0.0003350521,0.003578744,0.7917611,0.001721943,0.029368,0.1476605],"study_design_scores_gemma":[0.006303628,0.02984506,0.03595858,0.0003203311,0.0003812314,0.002547389,0.0002837078,0.009637311,0.7581696,0.0007899836,0.1556432,0.000120005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8689454,0.07177423,0.003999746,0.002189501,0.002345482,0.0007827569,0.005826511,0.0007316258,0.04340477],"genre_scores_gemma":[0.9630462,0.01395399,0.003107271,0.0008767588,0.0002973854,0.0001933512,0.006156145,0.00005070054,0.01231829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005498578,"threshold_uncertainty_score":0.01839459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1191869922770659,"score_gpt":0.3911136601934123,"score_spread":0.2719266679163465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}