{"id":"W3005219635","doi":"10.1016/j.bpj.2019.11.1088","title":"Dynamic Fingerprinting of the A2A Adenosine Receptor in Different Ligand-biased States","year":2020,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Förster resonance energy transfer; Chemistry; Adenosine A2A receptor; Biophysics; G protein-coupled receptor; Single-molecule FRET; Ligand (biochemistry); Molecular dynamics; Agonist; Adenosine receptor; Receptor; Stereochemistry; Fluorescence; Biochemistry; Computational chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001609396,0.0001448121,0.0001923111,0.000419862,0.0002916099,0.0005022331,0.000314363,0.0003238697,0.00357008],"category_scores_gemma":[0.0004005528,0.0001486433,0.0001524327,0.0002628376,0.0002672924,0.0004981359,0.000191554,0.0005305411,0.0004211795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002722314,"about_ca_system_score_gemma":0.0001280923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004921777,"about_ca_topic_score_gemma":0.0008109662,"domain_scores_codex":[0.9999331,0.000008544731,0.000002809689,0.00001623729,0.0000157217,0.00002351403],"domain_scores_gemma":[0.999855,0.00005021936,0.00002519076,0.00001760488,0.00002051408,0.00003146309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002797827,0.00003543298,0.0008238203,0.00004046103,0.00001734653,0.0001002235,0.00006966075,0.0002639224,0.9934841,0.001624745,0.000219481,0.00304122],"study_design_scores_gemma":[0.00008811542,0.00039866,0.06973156,0.0000410287,0.00009766761,0.001142102,0.0004089783,0.0276815,0.8938372,0.002971548,0.003512046,0.00008959031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919556,0.0005295883,0.003399666,0.000132868,0.00001427802,0.00000770232,0.0002483762,0.00006593344,0.003645981],"genre_scores_gemma":[0.9979264,0.0002886975,0.0006629992,0.00006813604,0.00001291606,0.00001638977,0.0001904669,0.00001913172,0.0008148573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00357008,"threshold_uncertainty_score":0.0119431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009218023800393339,"score_gpt":0.2267949408525521,"score_spread":0.2175769170521588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}