{"id":"W3005235125","doi":"10.1016/j.nicl.2020.102209","title":"Genome-wide association study of white matter hyperintensity volume in elderly persons without dementia","year":2020,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; GE Healthcare; National Key Research and Development Program of China; Johnson and Johnson; Janssen Research and Development; National Institutes of Health; H. Lundbeck A/S; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; University of Southern California; Merck; National Institute on Aging; Fujirebio Europe; Science and Technology Commission of Shanghai Municipality; Fudan University","keywords":"Genome-wide association study; Dementia; Minor allele frequency; Genetic association; Hyperintensity; Single-nucleotide polymorphism; Genetics; Allele; Biology; Medicine; Allele frequency; Disease; Gene; Internal medicine; Genotype; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008022383,0.0001347164,0.0004943262,0.00007826325,0.00005323398,0.00002171105,0.0001259491,0.00007866736,0.0009975643],"category_scores_gemma":[0.001644771,0.0001277419,0.0001520791,0.0002342445,0.0000612017,0.00008961751,0.000204758,0.0006065787,0.0002672884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003440311,"about_ca_system_score_gemma":0.00006765941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002357724,"about_ca_topic_score_gemma":0.00002467017,"domain_scores_codex":[0.9975762,0.0004222816,0.0006728343,0.0004807055,0.000538591,0.0003094377],"domain_scores_gemma":[0.9989173,0.0002283312,0.0001672087,0.0002308736,0.0002426381,0.000213669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004786675,0.001707503,0.9937514,0.00003941093,0.0001174326,0.0001782166,0.000687461,6.203333e-7,0.0007140773,6.465849e-8,0.002104361,0.0002208065],"study_design_scores_gemma":[0.004253629,0.004170351,0.9890589,0.00001268794,0.0002155999,0.000002244877,0.0007717554,0.0001756324,0.00002513949,0.000001578951,0.001220398,0.00009212043],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876524,0.00001164644,0.00008738492,0.009522793,0.00008269225,0.0008211043,0.000007008866,0.00002911731,0.001785829],"genre_scores_gemma":[0.9932064,0.0000107856,0.0001042917,0.00512644,0.0001072723,0.00001732197,0.00001043247,0.0000228691,0.00139418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005553982,"threshold_uncertainty_score":0.9999157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06009385341008332,"score_gpt":0.3612536182067581,"score_spread":0.3011597647966747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}