{"id":"W3005235125","doi":"10.1016/j.nicl.2020.102209","title":"Genome-wide association study of white matter hyperintensity volume in elderly persons without dementia","year":2020,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; GE Healthcare; National Key Research and Development Program of China; Johnson and Johnson; Janssen Research and Development; National Institutes of Health; H. Lundbeck A/S; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; University of Southern California; Merck; National Institute on Aging; Fujirebio Europe; Science and Technology Commission of Shanghai Municipality; Fudan University","keywords":"Genome-wide association study; Dementia; Minor allele frequency; Genetic association; Hyperintensity; Single-nucleotide polymorphism; Genetics; Allele; Biology; Medicine; Allele frequency; Disease; Gene; Internal medicine; Genotype; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003701746,0.0002580222,0.0003503234,0.0005173262,0.0003822177,0.0003596454,0.0002364526,0.0003858022,0.001431472],"category_scores_gemma":[0.0009715072,0.0001401101,0.0004260612,0.0007889204,0.0001664871,0.0001438179,0.0002518729,0.0003585016,0.0001746724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009216124,"about_ca_system_score_gemma":0.0001327453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002762802,"about_ca_topic_score_gemma":0.004035545,"domain_scores_codex":[0.9997951,0.00004923254,0.00002681131,0.00007386114,0.00002926405,0.00002561864],"domain_scores_gemma":[0.9995759,0.00008884224,0.0001702456,0.00004880164,0.0000483354,0.00006781365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004637577,0.00005093671,0.993251,0.00002911615,0.0005412082,0.0002682552,0.00006792244,0.00005789085,0.002349145,0.00002745262,0.0001410798,0.002751991],"study_design_scores_gemma":[0.000008554168,0.00005708642,0.9993197,0.000003310527,0.0001064528,0.0001882064,0.00003141531,0.00006725475,0.00009584925,0.00002779409,0.00009275978,0.000001620806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988897,0.0005245614,0.00009780355,0.00003398246,0.000009759116,0.000003036007,0.0002242047,0.000005276979,0.0002117206],"genre_scores_gemma":[0.9992663,0.0001787748,0.00009271964,0.00002274937,0.00001348378,0.000003567101,0.0002411809,0.00000159354,0.0001796041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002762802,"threshold_uncertainty_score":0.005493402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06009385341008332,"score_gpt":0.3612536182067581,"score_spread":0.3011597647966747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}