{"id":"W3005239301","doi":"10.1016/j.bpj.2019.11.1568","title":"Conformational Dynamics of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Revealed by Molecular Simulations","year":2020,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; Chloride channel; Molecular dynamics; POPC; Chemistry; Lipid bilayer; Biophysics; Transmembrane protein; Conductance; Cystic fibrosis; Bilayer; Biochemistry; Membrane; Biology; Computational chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003326845,0.0007032339,0.000858739,0.0004596201,0.001209633,0.0008217996,0.001089489,0.001276788,0.002764268],"category_scores_gemma":[0.001235542,0.0005572102,0.0006355304,0.0004510461,0.001044211,0.001192941,0.0006572583,0.001560587,0.0002870527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00126352,"about_ca_system_score_gemma":0.001541023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009811749,"about_ca_topic_score_gemma":0.00646958,"domain_scores_codex":[0.9997939,0.00003908429,0.000006721038,0.00003049047,0.00005262748,0.00007715073],"domain_scores_gemma":[0.9996436,0.000160384,0.00003337043,0.00003936928,0.00005241397,0.00007089358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005502934,0.0003976969,0.003073779,0.0001182926,0.00009356168,0.0004515419,0.0002906482,0.9546703,0.02010615,0.0158863,0.001332946,0.003028589],"study_design_scores_gemma":[0.00008181449,0.00007923638,0.0008361383,0.00001200488,0.00001464331,0.00001668462,0.0000573694,0.9956316,0.001201881,0.001719519,0.0003340641,0.00001508384],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836279,0.0002818408,0.005805391,0.0006306366,0.00007983958,0.00005157107,0.0003482328,0.0001531608,0.009021387],"genre_scores_gemma":[0.9954255,0.0002603421,0.0029291,0.0001166113,0.00001935385,0.00007079629,0.0003408254,0.00005533016,0.0007820791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009811749,"threshold_uncertainty_score":0.01950932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314188726691251,"score_gpt":0.2837443673902639,"score_spread":0.2706024801233514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}