{"id":"W3005283613","doi":"10.1021/acs.molpharmaceut.0c00069","title":"Reduced Heart Exposure of Diclofenac by Its Polymeric Micellar Formulation Normalizes CYP-Mediated Metabolism of Arachidonic Acid Imbalance in An Adjuvant Arthritis Rat Model: Implications in Reduced Cardiovascular Side Effects of Diclofenac by Nanodrug Delivery","year":2020,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Diclofenac; Pharmacology; Chemistry; Arachidonic acid; Pharmacokinetics; Cardiotoxicity; Celecoxib; Arthritis; In vivo; Bioavailability; Intraperitoneal injection; Micelle; Toxicity; Medicine; Biochemistry; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002244121,0.0005584759,0.0004426632,0.000372852,0.0001536853,0.0002717838,0.000208803,0.0005216147,0.001087028],"category_scores_gemma":[0.000156133,0.0001754067,0.0003491231,0.0001163091,0.0002806259,0.0004274057,0.000146643,0.0008704603,0.0002386033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254854,"about_ca_system_score_gemma":0.000216904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005765735,"about_ca_topic_score_gemma":0.001114978,"domain_scores_codex":[0.999818,0.00002274058,0.00001368988,0.00005076368,0.00004120828,0.00005357292],"domain_scores_gemma":[0.9998226,0.00001356588,0.00006902976,0.00001801087,0.00002825313,0.0000486198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001922326,0.00004995272,0.00005049389,0.00001689953,0.000003268887,0.000009121903,0.000005900573,0.000013311,0.9988635,0.00001628197,0.000008627208,0.0007705853],"study_design_scores_gemma":[0.00002319218,0.001478505,0.001066834,0.000003676485,0.00002388508,0.00004945523,0.00001146374,0.0002608135,0.9965312,0.00001075658,0.0005364637,0.000003776146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930785,0.001530871,0.004409974,0.0001473402,0.00006674299,0.00005354896,0.0001393239,0.00009105033,0.0004826665],"genre_scores_gemma":[0.9896525,0.001616517,0.005309472,0.0001024309,0.00003581232,0.00009152769,0.0002820093,0.00003297786,0.002876662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087028,"threshold_uncertainty_score":0.003636539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226666037524556,"score_gpt":0.2626451153212417,"score_spread":0.2503784549459962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}