{"id":"W3005289851","doi":"10.1038/s41375-020-0718-z","title":"Daratumumab monotherapy for patients with intermediate-risk or high-risk smoldering multiple myeloma: a randomized, open-label, multicenter, phase 2 study (CENTAURUS)","year":2020,"lang":"en","type":"article","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Cilag; National Cancer Institute; Pharmacyclics; Chugai Pharmaceutical; Janssen Research and Development; National Institutes of Health; Glenmark Pharmaceuticals; Adaptive Biotechnologies; Array BioPharma; Yale University; Raymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences, Yale University; Sanofi; Celgene; Bristol-Myers Squibb; AstraZeneca; Amgen; Winship Cancer Institute; Pfizer; Memorial Sloan-Kettering Cancer Center; Multiple Myeloma Research Foundation","keywords":"Clinical endpoint; Medicine; Dosing; Internal medicine; Multiple myeloma; Gastroenterology; Confidence interval; Phases of clinical research; Surgery; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003270184,0.001599345,0.002644548,0.0006237833,0.000462554,0.001449465,0.000627916,0.001398257,0.002429905],"category_scores_gemma":[0.001741212,0.0007847014,0.002141648,0.0005283341,0.001317866,0.0009418489,0.0005141508,0.002490079,0.0006381125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008889515,"about_ca_system_score_gemma":0.001323052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008426937,"about_ca_topic_score_gemma":0.001795089,"domain_scores_codex":[0.9990193,0.0006192479,0.0000442794,0.0001301851,0.00007025237,0.0001166836],"domain_scores_gemma":[0.9989983,0.0002083499,0.0002092248,0.0001002752,0.00006781862,0.0004160298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9569387,0.01374163,0.002687846,0.0003350432,0.0008707496,0.00004996302,0.00008712284,0.0003913321,0.005972846,0.0001392239,0.0009997751,0.01778579],"study_design_scores_gemma":[0.8775074,0.1158946,0.004741753,0.00001495776,0.0003830187,0.00004845778,0.00001645853,0.0004328535,0.0003723689,0.00007103113,0.0004968,0.00002023752],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949847,0.001660652,0.0002765262,0.000342154,0.0001651829,0.001324823,0.0004004052,0.00005644511,0.0007889497],"genre_scores_gemma":[0.9936028,0.0009377838,0.001166606,0.0007973599,0.0003378399,0.001543017,0.0007738422,0.00001605709,0.0008247875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003270184,"threshold_uncertainty_score":0.01729459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03634479394324643,"score_gpt":0.3299823469909974,"score_spread":0.293637553047751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}