{"id":"W3005294305","doi":"10.21037/atm.2020.01.117","title":"The recent failure of the PROMESA clinical trial for multiple system atrophy raises the question—are polyphenols a viable therapeutic option against proteinopathies?","year":2020,"lang":"en","type":"letter","venue":"Annals of Translational Medicine","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Weston Brain Institute; CurePSP; National Institute of Neurological Disorders and Stroke; California Department of Public Health; Alzheimer's Association; Parkinson Alliance; Michael J. Fox Foundation for Parkinson's Research","keywords":"Medicine; Atrophy; Bioinformatics; Clinical trial; Intensive care medicine; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001036783,0.0004025969,0.000994141,0.00008053316,0.0003662157,0.00001725936,0.0004143453,0.0003804156,0.00001744454],"category_scores_gemma":[0.0007361686,0.0001762238,0.0006879612,0.0003013555,0.0004987642,0.00005478228,0.00002600839,0.0007777504,0.000003252784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003444761,"about_ca_system_score_gemma":0.0004862511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002457849,"about_ca_topic_score_gemma":0.00001082464,"domain_scores_codex":[0.9959495,0.0006249068,0.001338279,0.000472079,0.001276524,0.0003386874],"domain_scores_gemma":[0.995781,0.001420645,0.001219751,0.0006421501,0.0008264082,0.0001100545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1784221,0.00285465,0.006428286,0.01431298,0.01543434,0.0002294083,0.001629939,0.0001651068,0.002373323,0.008988715,0.6672543,0.1019068],"study_design_scores_gemma":[0.0454243,0.003600179,0.004249365,0.004528756,0.002158451,0.00001419425,0.0003042479,0.0008585737,0.0008206089,0.002581722,0.9351777,0.0002818784],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.005490356,0.006729561,0.0008771947,0.9750603,0.001004948,0.01008371,0.0006262182,0.00004746834,0.00008020513],"genre_scores_gemma":[0.8337,0.00156457,0.0005128086,0.1524847,0.008086858,0.002211531,0.001046708,0.0001187217,0.0002741486],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.8282096,"threshold_uncertainty_score":0.7186198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.137096770846231,"score_gpt":0.3783598271249737,"score_spread":0.2412630562787427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}