{"id":"W3005328263","doi":"10.1016/j.neuron.2020.01.008","title":"Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors","year":2020,"lang":"en","type":"article","venue":"Neuron","topic":"Plant Reproductive Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; McGill University Health Centre; Montreal Neurological Institute and Hospital; McGill University; University of British Columbia","funders":"National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; Japan Society for the Promotion of Science; Fudan University; European Research Council; Natural Sciences and Engineering Research Council of Canada; Max-Planck-Gesellschaft; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Chinese Academy of Sciences; Japan Science and Technology Agency; Howard Hughes Medical Institute; National Natural Science Foundation of China; Deutsche Forschungsgemeinschaft; European Commission; Simons Foundation Autism Research Initiative; National Eye Institute; Ministry of Education, Culture, Sports, Science and Technology; National Institute of Mental Health; Science and Technology Commission of Shanghai Municipality; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation; European Molecular Biology Organization; Canadian Institutes of Health Research","keywords":"Germline; Recombinase; Biology; Genetics; Cre recombinase; Recombination; Locus (genetics); Gene; Homologous recombination; Transgene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006863447,0.0006751594,0.0005290862,0.0005273613,0.0002081792,0.0006797817,0.0004701138,0.0003974938,0.00168377],"category_scores_gemma":[0.0007150219,0.0003776743,0.0002640978,0.0002938938,0.000325166,0.0004353464,0.0005613511,0.0006430657,0.00044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003928995,"about_ca_system_score_gemma":0.0003650798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007314584,"about_ca_topic_score_gemma":0.002742929,"domain_scores_codex":[0.9990927,0.000145879,0.00009595304,0.0002593278,0.0002295402,0.0001765729],"domain_scores_gemma":[0.9991516,0.0002775505,0.0002576734,0.0001081357,0.0001052536,0.00009984637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002241491,0.00001227834,0.0003533241,0.00001128816,0.000003663501,0.00001264925,0.000007053365,0.00004384656,0.9988311,0.00004061127,0.000005294872,0.0006565102],"study_design_scores_gemma":[0.000006534005,0.00006681753,0.003665079,0.000003983901,0.00003460407,0.0001087772,0.00002305908,0.0006482677,0.9946371,0.00002784819,0.000772786,0.000005070938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651226,0.0005406362,0.03190507,0.00007407158,0.00001892943,0.00009648123,0.0002275192,0.000274152,0.00174055],"genre_scores_gemma":[0.9740399,0.0005479575,0.02086762,0.00008026518,0.000008062403,0.00009632217,0.000444683,0.0004522622,0.003463031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00168377,"threshold_uncertainty_score":0.005632758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131214825067798,"score_gpt":0.2068473676536452,"score_spread":0.1937258851468654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}