{"id":"W3005328263","doi":"10.1016/j.neuron.2020.01.008","title":"Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors","year":2020,"lang":"en","type":"article","venue":"Neuron","topic":"Plant Reproductive Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; McGill University Health Centre; Montreal Neurological Institute and Hospital; McGill University; University of British Columbia","funders":"National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; Japan Society for the Promotion of Science; Fudan University; European Research Council; Natural Sciences and Engineering Research Council of Canada; Max-Planck-Gesellschaft; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Chinese Academy of Sciences; Japan Science and Technology Agency; Howard Hughes Medical Institute; National Natural Science Foundation of China; Deutsche Forschungsgemeinschaft; European Commission; Simons Foundation Autism Research Initiative; National Eye Institute; Ministry of Education, Culture, Sports, Science and Technology; National Institute of Mental Health; Science and Technology Commission of Shanghai Municipality; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation; European Molecular Biology Organization; Canadian Institutes of Health Research","keywords":"Germline; Recombinase; Biology; Genetics; Cre recombinase; Recombination; Locus (genetics); Gene; Homologous recombination; Transgene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007522817,0.0001254107,0.0001452136,0.00002351412,0.00004177185,0.000008041614,0.00009657239,0.00007547376,0.000002140927],"category_scores_gemma":[0.00009602711,0.0001043063,0.00002334549,0.00006406882,0.00005385889,0.000007190692,0.00007757115,0.0000789,6.910958e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001107387,"about_ca_system_score_gemma":0.00001969595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006870465,"about_ca_topic_score_gemma":8.555624e-7,"domain_scores_codex":[0.9991027,0.00006992384,0.0001827822,0.0004391945,0.00007509446,0.0001303077],"domain_scores_gemma":[0.9995376,0.00001545096,0.0001501921,0.0001498744,0.00009540009,0.00005150837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000085106,0.000009774723,0.02159638,0.0001897812,0.00001207866,0.000004970012,0.0001814293,0.0005771024,0.9770743,0.000007702764,0.00003911681,0.0002222728],"study_design_scores_gemma":[0.0003760586,0.0007495176,0.05829492,0.00004828567,0.00002271217,0.00003202629,0.0001601821,0.0003998826,0.9384522,8.495666e-7,0.001282113,0.0001812562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980114,0.001020133,0.0005962153,0.00006586224,0.00007096559,0.0001592016,0.0000186107,0.0000202027,0.00003748544],"genre_scores_gemma":[0.9979162,0.0002601686,0.001539448,0.00004400742,0.0001427472,0.000003739197,0.0000595383,0.00001571362,0.00001846362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03862209,"threshold_uncertainty_score":0.4253486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131214825067798,"score_gpt":0.2068473676536452,"score_spread":0.1937258851468654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}