{"id":"W3005356559","doi":"10.1177/2050313x20905672","title":"Dose optimization of brodalumab in moderate-to-severe plaque psoriasis: A case report","year":2020,"lang":"en","type":"article","venue":"SAGE Open Medical Case Reports","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Health Sciences Centre; Women's College Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Psoriasis; Regimen; Dosing; Plaque psoriasis; Maintenance dose; Dermatology; Maintenance therapy; Pharmacology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000461188,0.002229959,0.001615251,0.002244228,0.002764776,0.002199305,0.001491369,0.007610802,0.001985418],"category_scores_gemma":[0.002281988,0.001327053,0.001730646,0.001491062,0.001823055,0.002053618,0.001212199,0.004607184,0.0008699371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00150565,"about_ca_system_score_gemma":0.0008312299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001675104,"about_ca_topic_score_gemma":0.001971818,"domain_scores_codex":[0.9990305,0.0001714828,0.00008130769,0.0002328231,0.0001890109,0.0002948551],"domain_scores_gemma":[0.9986841,0.0004023031,0.0003067073,0.00015228,0.00006378947,0.0003907549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00001973746,0.00005424173,0.001296477,0.00002272141,0.000007378567,0.9966561,0.00007089915,0.00006020382,0.0004159709,0.0001708596,0.0002088416,0.001016542],"study_design_scores_gemma":[0.000007823718,0.00003128302,0.0005154909,0.000006383371,0.000007424605,0.9986046,0.0000310233,0.0001893466,0.0002336313,0.00007845704,0.0002892105,0.000005362445],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9301921,0.0164865,0.01481263,0.01046568,0.000874415,0.0005770858,0.0002582516,0.0005765608,0.02575684],"genre_scores_gemma":[0.9888602,0.002570432,0.003296474,0.001383483,0.001280003,0.00004588988,0.00006664227,0.00003629053,0.002460571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007610802,"threshold_uncertainty_score":0.01092428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02648647769300032,"score_gpt":0.2825109118744372,"score_spread":0.2560244341814368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}