{"id":"W3005374599","doi":"10.1016/j.nbd.2020.104787","title":"Transient upregulation of translational efficiency in prodromal and early symptomatic Tg2576 mice contributes to Aβ pathology","year":2020,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Collegio Ghislieri di Pavia; Ministero della Salute; Ministry of Health, British Columbia; National Research Council; FRAXA Research Foundation; Fondazione Umberto Veronesi; Alzheimer's Association","keywords":"Downregulation and upregulation; Transient (computer programming); Neuroscience; Medicine; Pathology; Psychology; Biology; Computer science; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327395,0.0006841975,0.0003798228,0.0006097889,0.0002189023,0.0003558955,0.0001996675,0.0004718052,0.001166832],"category_scores_gemma":[0.0001359135,0.0003140796,0.0004215265,0.0001957219,0.0003890062,0.0002633121,0.0002334998,0.0009866887,0.0004631011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003589684,"about_ca_system_score_gemma":0.0002204682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008056425,"about_ca_topic_score_gemma":0.001844204,"domain_scores_codex":[0.9998388,0.00001058334,0.00001755022,0.00004027028,0.00003228835,0.00006041175],"domain_scores_gemma":[0.9997532,0.00001270542,0.00007918696,0.00001744719,0.00001844687,0.0001190119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001890252,0.00004110314,0.0003233857,0.00001759742,0.000004548217,0.0001145081,0.00002008743,0.00001302234,0.9988661,0.00002492673,0.00001803377,0.0003677334],"study_design_scores_gemma":[0.0000687261,0.002011537,0.08988092,0.0000301314,0.00006664238,0.00116025,0.0001796615,0.000512235,0.904474,0.0001774397,0.001416167,0.00002234349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998212,0.0004939224,0.0003692541,0.00003872889,0.0000133564,0.00001743781,0.0003193123,0.00006280177,0.0004732069],"genre_scores_gemma":[0.994794,0.0005440161,0.0007704319,0.00005836763,0.00001406135,0.00007192836,0.0006416774,0.00003803492,0.003067411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166832,"threshold_uncertainty_score":0.003903389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005530504840362648,"score_gpt":0.2145415912165284,"score_spread":0.2090110863761657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}