{"id":"W3005379438","doi":"10.1093/braincomms/fcaa007","title":"Neuroanatomical spread of amyloid β and tau in Alzheimer’s disease: implications for primary prevention","year":2020,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Pfizer; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Precuneus; Temporal lobe; Clinical Dementia Rating; Posterior cingulate; Entorhinal cortex; Neuroscience; Disease; Dementia; Alzheimer's disease; Medicine; Temporal cortex; Psychology; Biomarker; Fusiform gyrus; Pathology; Cognition; Hippocampus; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001689025,0.00006465069,0.0001439291,0.00007403501,0.00007032334,0.0000112419,0.0002093574,0.00002649102,0.00001748666],"category_scores_gemma":[0.0003937109,0.0000665805,0.00005975953,0.0002196894,0.0001549078,0.00007353301,0.0002091117,0.0001168342,0.000002839212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001578115,"about_ca_system_score_gemma":0.0001495595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008778055,"about_ca_topic_score_gemma":0.00001128531,"domain_scores_codex":[0.9992957,0.0001046148,0.0002346386,0.0001561574,0.0000883776,0.0001205666],"domain_scores_gemma":[0.998776,0.0003932516,0.00005509227,0.0005018429,0.0001148344,0.0001590211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007690506,0.00241188,0.7160982,0.00043966,0.0002575353,0.000002049343,0.0006721591,0.000002496319,0.03654607,0.03453123,0.008172066,0.2000976],"study_design_scores_gemma":[0.001239925,0.0001846961,0.9854161,0.00005026418,0.0001185103,0.000002121581,0.00005902851,0.0007427061,0.0002160221,0.001933642,0.009977665,0.00005938208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5093066,0.005043944,0.003584856,0.4736664,0.00001319972,0.003548623,0.0002036309,0.0000686372,0.004564097],"genre_scores_gemma":[0.9942289,0.0004259506,0.002705619,0.001860324,0.00001514308,0.0003542461,0.0003319429,0.0000119386,0.00006592121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4849223,"threshold_uncertainty_score":0.2715074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08202261746121772,"score_gpt":0.3870654734171458,"score_spread":0.3050428559559281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}