{"id":"W3005406102","doi":"10.1371/journal.pgen.1008597","title":"Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; Canadian Institutes of Health Research","keywords":"Cell division control protein 4; Biology; Ubiquitin ligase; Cell biology; Cullin; Genetics; Saccharomyces cerevisiae; Ubiquitin; F-box protein; Chromosome segregation; Gene; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052669,0.0003260545,0.000193385,0.0001961276,0.000116231,0.0002344139,0.0002577242,0.0001576703,0.0008066465],"category_scores_gemma":[0.0000768258,0.0001347975,0.0001898515,0.0001254071,0.0001305026,0.00008529752,0.0001792258,0.000208128,0.0002307165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801795,"about_ca_system_score_gemma":0.0002744351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00114344,"about_ca_topic_score_gemma":0.001627696,"domain_scores_codex":[0.9998976,0.00001296033,0.00001420587,0.0000172451,0.00003488459,0.00002307022],"domain_scores_gemma":[0.9999094,0.00001465063,0.00002770442,0.000009739172,0.000006133258,0.00003245143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001186378,0.0000272882,0.0002760395,0.00002102415,0.000006237957,0.00004340622,0.000004009038,0.00008207421,0.9988104,0.00003645586,0.00002422417,0.0005503989],"study_design_scores_gemma":[0.00001368864,0.0001460915,0.005567404,0.000002887896,0.00001325843,0.0001828457,0.00001613181,0.0009982415,0.9918562,0.00001999988,0.001180845,0.00000240231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976892,0.0006903028,0.0007526354,0.00002639164,0.000008159812,0.00001285091,0.0003105503,0.00004615937,0.0004636816],"genre_scores_gemma":[0.9961213,0.0003082888,0.0007638098,0.00001759338,0.000001583719,0.00001479267,0.0006320148,0.00001135052,0.002129117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00114344,"threshold_uncertainty_score":0.002698541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03374166335683126,"score_gpt":0.2677071603786116,"score_spread":0.2339654970217803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}