{"id":"W3005406102","doi":"10.1371/journal.pgen.1008597","title":"Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; Canadian Institutes of Health Research","keywords":"Cell division control protein 4; Biology; Ubiquitin ligase; Cell biology; Cullin; Genetics; Saccharomyces cerevisiae; Ubiquitin; F-box protein; Chromosome segregation; Gene; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001854467,0.0001858034,0.0003162158,0.00006331685,0.00003741592,0.00001285676,0.0002292371,0.0001975577,0.00002586565],"category_scores_gemma":[0.0004165034,0.0001870572,0.00008863126,0.0002832597,0.0001530361,0.000004475678,0.0002137244,0.00009634769,0.000001463258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001530289,"about_ca_system_score_gemma":0.0001313668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001108274,"about_ca_topic_score_gemma":0.00003347458,"domain_scores_codex":[0.9983347,0.0001140593,0.0004939757,0.0004494691,0.0003029462,0.0003048626],"domain_scores_gemma":[0.9990788,0.00003268204,0.0001622773,0.0002760717,0.0002879198,0.0001622252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002290524,0.0002510063,0.04444239,0.0006670192,0.00007390616,7.975946e-7,0.0002743956,0.0004237668,0.9529604,0.000005858022,0.0000359839,0.0006353928],"study_design_scores_gemma":[0.001019983,0.0007201818,0.00173747,0.00005371639,0.00004080733,9.215007e-7,0.0001170114,0.01573987,0.9800013,0.00003421511,0.0003716588,0.0001629136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966447,0.001156318,0.0007309954,0.0001101141,0.00002846901,0.000931472,0.0003391021,0.000006436509,0.0000524405],"genre_scores_gemma":[0.9967917,0.0004405065,0.002269774,0.00003984813,0.000090653,0.00006195223,0.0002514229,0.00003372004,0.00002046561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04270492,"threshold_uncertainty_score":0.7627972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03374166335683126,"score_gpt":0.2677071603786116,"score_spread":0.2339654970217803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}