{"id":"W3005425030","doi":"10.1038/s41419-020-2305-7","title":"G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre; University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; Government of Canada; Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research; National Institute for Health and Care Research; Rutgers Cancer Institute of New Jersey; Robert Wood Johnson Foundation","keywords":"Triple-negative breast cancer; Cancer research; Kisspeptin; Glutaminolysis; Estrogen receptor; Breast cancer; Glutamine; Biology; Glutaminase; Metastasis; Progesterone receptor; Internal medicine; Carcinogenesis; Estrogen receptor alpha; Invadopodia; Endocrinology; Cancer; Cancer cell; Medicine; Hormone; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644979,0.0002761752,0.0004919181,0.0000929796,0.0000791363,0.0000455001,0.00007235452,0.00006207699,0.0001480761],"category_scores_gemma":[0.000460421,0.0002370145,0.00007744958,0.0002520999,0.0001174268,0.0001526668,0.0000759704,0.000185833,0.00001776748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003979757,"about_ca_system_score_gemma":0.0002848448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003832628,"about_ca_topic_score_gemma":0.000005089677,"domain_scores_codex":[0.9982527,0.00007860278,0.0002876747,0.0008130945,0.00022263,0.0003453067],"domain_scores_gemma":[0.9984524,0.00004117351,0.0001145057,0.0002547463,0.0001113155,0.001025884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003761801,0.000479119,0.5636091,0.0005687165,0.0001550647,0.0001705932,0.001697658,0.000006691026,0.3764729,0.0001563215,0.0001207929,0.05280126],"study_design_scores_gemma":[0.00615775,0.0003025276,0.9566392,0.0002273226,0.0005355561,0.00001743379,0.001010561,0.0008960626,0.03108762,0.0001919817,0.002315121,0.0006188431],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749921,0.01772999,0.00001074581,0.005654467,0.00004321337,0.00132474,0.00007697663,0.00007240928,0.00009533495],"genre_scores_gemma":[0.9967824,0.0008183513,0.001037177,0.0003703073,0.0004268404,0.0002989465,0.00002113244,0.00003854487,0.0002062672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3930301,"threshold_uncertainty_score":0.9665172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712999701005783,"score_gpt":0.2492082848512943,"score_spread":0.2320782878412365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}