{"id":"W3005425030","doi":"10.1038/s41419-020-2305-7","title":"G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre; University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; Government of Canada; Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research; National Institute for Health and Care Research; Rutgers Cancer Institute of New Jersey; Robert Wood Johnson Foundation","keywords":"Triple-negative breast cancer; Cancer research; Kisspeptin; Glutaminolysis; Estrogen receptor; Breast cancer; Glutamine; Biology; Glutaminase; Metastasis; Progesterone receptor; Internal medicine; Carcinogenesis; Estrogen receptor alpha; Invadopodia; Endocrinology; Cancer; Cancer cell; Medicine; Hormone; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054855,0.0001410009,0.0003199269,0.0002200194,0.000136311,0.0002308593,0.00007142602,0.0001896782,0.001145223],"category_scores_gemma":[0.00009015453,0.00008872098,0.000209144,0.0001707368,0.0001827508,0.0001149895,0.0001961551,0.0003907534,0.000223554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002860193,"about_ca_system_score_gemma":0.0002049842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004183131,"about_ca_topic_score_gemma":0.0009196269,"domain_scores_codex":[0.9999214,0.00001693723,0.000005539588,0.00001478602,0.00001632629,0.0000250314],"domain_scores_gemma":[0.9999585,0.00000685187,0.00001085496,0.000004765946,0.000003804976,0.00001523573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005237933,0.0000398002,0.0008495845,0.00005297418,0.00001029622,0.0003108994,0.00003096889,0.00005662228,0.9952033,0.0001190289,0.000106288,0.002696481],"study_design_scores_gemma":[0.0001007642,0.002414049,0.05350112,0.00001950123,0.00006486364,0.003173987,0.0003251809,0.001328056,0.9290474,0.0004091663,0.0095976,0.00001818898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956344,0.002670601,0.0004531764,0.0001169609,0.00003523646,0.00001234408,0.000165365,0.00003247045,0.0008794438],"genre_scores_gemma":[0.997027,0.001096755,0.0002570181,0.00005989247,0.000006630349,0.00001285473,0.0001795886,0.000007666441,0.001352732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145223,"threshold_uncertainty_score":0.003831148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712999701005783,"score_gpt":0.2492082848512943,"score_spread":0.2320782878412365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}