{"id":"W3005434682","doi":"10.1101/2020.02.10.941682","title":"High throughput screening identifies SOX2 as a Super Pioneer Factor that inhibits DNA methylation maintenance at its binding sites","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Institute of Genetics and Genomics of Geneva; Novartis Stiftung für Medizinisch-Biologische Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Université de Genève; Novartis Foundation","keywords":"DNA demethylation; DNA methylation; Biology; Chromatin; Epigenomics; Histone methylation; Epigenetics; Nucleosome; Pioneer factor; Histone; Transcription factor; Methylation; DNA; Epigenetics of physical exercise; Cell biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000292644,0.0004082256,0.000444868,0.0003253279,0.0001832309,0.0002741249,0.0003377316,0.0003141242,0.001378701],"category_scores_gemma":[0.0001936431,0.0001682506,0.0002942471,0.0002384062,0.0001820459,0.00007798435,0.0001661493,0.0003304084,0.0004850421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002292222,"about_ca_system_score_gemma":0.0002140736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008983587,"about_ca_topic_score_gemma":0.001607273,"domain_scores_codex":[0.9997607,0.00003525047,0.00001266648,0.0000467016,0.0001032259,0.00004148184],"domain_scores_gemma":[0.9998729,0.00004623142,0.0000183012,0.00001847727,0.00001384089,0.00003014844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006036284,0.00005688422,0.0002233359,0.00001057678,0.000007011945,0.00002809053,0.000002851237,0.00008139885,0.9983532,0.00001997235,0.00005200427,0.00110436],"study_design_scores_gemma":[0.00002819017,0.0004468724,0.002962363,0.000001272717,0.00002110054,0.0001622491,0.000006539279,0.001709081,0.9934256,0.00001758256,0.001214949,0.000004172708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832032,0.001581178,0.01200273,0.0001292374,0.00002853784,0.0001235796,0.001021142,0.000253773,0.001656568],"genre_scores_gemma":[0.9825309,0.0007121387,0.00897023,0.00008832767,0.00001828267,0.00008739659,0.002683901,0.00004368761,0.004865258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378701,"threshold_uncertainty_score":0.004612267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03139644547504665,"score_gpt":0.2491036907304996,"score_spread":0.2177072452554529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}