{"id":"W3005464002","doi":"10.1016/j.yrtph.2020.104614","title":"Organic compounds percutaneous penetration in vivo in man: Relationship to mathematical predictive model","year":2020,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"In vivo; Flux (metallurgy); Organic chemicals; Penetration (warfare); Predictive value; Mathematical model; Biological system; Biochemical engineering; Experimental data; Chemistry; Computer science; Mathematics; Statistics; Environmental chemistry; Biology; Operations research; Biotechnology; Organic chemistry; Medicine; Engineering; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006304599,0.0003736102,0.000577599,0.0003059254,0.0001980648,0.00001131442,0.0003235014,0.0007691604,0.003542264],"category_scores_gemma":[0.0001234707,0.0004274861,0.00006009204,0.0004575645,0.00042605,0.0002193803,0.000161237,0.001472312,0.0001544171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754778,"about_ca_system_score_gemma":0.0001787594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002031388,"about_ca_topic_score_gemma":0.00004994484,"domain_scores_codex":[0.9966825,0.0009320905,0.0007545132,0.0007439819,0.0001721979,0.0007146939],"domain_scores_gemma":[0.9982709,0.000909297,0.0001217006,0.0001515454,0.00005903619,0.0004875285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.004063434,0.001092803,0.05168253,0.0002831031,0.0001755979,0.0008087456,0.009348905,0.2102339,0.7065295,0.008536638,0.006415174,0.000829735],"study_design_scores_gemma":[0.009645533,0.001637167,0.02686649,0.00005755412,0.0004464244,0.0006957537,0.0008354805,0.8796974,0.0561075,0.010803,0.01175161,0.001456125],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856009,0.00033171,0.003560925,0.006111703,0.0004711644,0.001243863,0.0000592633,0.0001131319,0.00250738],"genre_scores_gemma":[0.9810315,0.00013031,0.0009198195,0.01720601,0.0001696619,0.000156878,0.00001468617,0.00004441516,0.0003266778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6694635,"threshold_uncertainty_score":0.9998177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08625775938483848,"score_gpt":0.3882800673891639,"score_spread":0.3020223080043254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}