{"id":"W3005485234","doi":"10.3389/fimmu.2020.00150","title":"Sedimentation Velocity Analytical Ultracentrifugation of Oxidized Recombinant Full-Length Factor VIII","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Immunogenicity; Recombinant DNA; Immune system; Ultracentrifuge; Chemistry; Coagulation; Chinese hamster ovary cell; Antibody; Immunology; Biochemistry; Medicine; Internal medicine; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005872401,0.0006426916,0.0004456065,0.0005957746,0.0002865772,0.0003823032,0.0003601798,0.0002475647,0.0005468456],"category_scores_gemma":[0.0005002524,0.0001485204,0.000287108,0.0006876202,0.0002210968,0.0002384826,0.0002107516,0.001143203,0.0002594077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000385837,"about_ca_system_score_gemma":0.0005162942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0036936,"about_ca_topic_score_gemma":0.00451172,"domain_scores_codex":[0.9996986,0.00005737271,0.0000296818,0.00005160411,0.0001075418,0.00005524651],"domain_scores_gemma":[0.9996638,0.0000767525,0.00005677532,0.00003418151,0.0001277104,0.0000407453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002587635,0.0001727345,0.001622773,0.00009914495,0.00004587217,0.0001290151,0.0003934891,0.0001894525,0.9906501,0.0004293034,0.0002072543,0.005802227],"study_design_scores_gemma":[0.00005367586,0.001516766,0.02083926,0.0001037123,0.0001073325,0.000310178,0.0002052115,0.01300884,0.9552239,0.0003087469,0.008287904,0.00003445163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739994,0.00390147,0.01785513,0.0001757008,0.0001417525,0.000209843,0.0006776568,0.0001886802,0.002850363],"genre_scores_gemma":[0.939128,0.003746503,0.04698114,0.0001626223,0.000053811,0.0002012628,0.003712665,0.0001154002,0.00589853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0036936,"threshold_uncertainty_score":0.007344246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783113571486913,"score_gpt":0.2967663861510991,"score_spread":0.26893525043623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}