{"id":"W3005500171","doi":"10.2196/16664","title":"Evaluation of the Safety and Efficacy of Avacopan, a C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Treated Concomitantly With Rituximab or Cyclophosphamide/Azathioprine: Protocol for a Randomized, Double-Blind, Active-Controlled, Phase 3 Trial","year":2020,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Azathioprine; Vasculitis; Anti-neutrophil cytoplasmic antibody; Rituximab; Prednisone; Internal medicine; Immunology; Cyclophosphamide; C5a receptor; Randomized controlled trial; Gastroenterology; Antibody; Disease; Complement system; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009025502,0.002906804,0.003989312,0.0006725749,0.001477489,0.001797672,0.002068603,0.003314509,0.01371621],"category_scores_gemma":[0.006432755,0.001084966,0.002685459,0.0008307968,0.002008963,0.001579313,0.0007476421,0.00410055,0.002580191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002198107,"about_ca_system_score_gemma":0.004739157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00111625,"about_ca_topic_score_gemma":0.002054183,"domain_scores_codex":[0.9960037,0.002494626,0.0002777237,0.0004578179,0.0003109943,0.0004551974],"domain_scores_gemma":[0.9958816,0.0008233348,0.0009972637,0.0004612537,0.0005326659,0.001303911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9837255,0.005996381,0.0005026719,0.0005847735,0.000486024,0.00004665403,0.00005518646,0.0003303293,0.001896004,0.000108542,0.0009885846,0.005279289],"study_design_scores_gemma":[0.9580972,0.03861139,0.001129016,0.00005461186,0.000232232,0.00002868089,0.0000123758,0.0002424507,0.0002877301,0.0001436062,0.001146309,0.00001438258],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.512635,0.003417612,0.003764349,0.001542118,0.0009186463,0.4620426,0.007479508,0.0003648708,0.007835475],"genre_scores_gemma":[0.5210823,0.001891661,0.007590347,0.002560844,0.0005813161,0.457026,0.004603348,0.00006116413,0.004603133],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01371621,"threshold_uncertainty_score":0.047732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09934384377507725,"score_gpt":0.4612189236047359,"score_spread":0.3618750798296587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}