{"id":"W3005500171","doi":"10.2196/16664","title":"Evaluation of the Safety and Efficacy of Avacopan, a C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Treated Concomitantly With Rituximab or Cyclophosphamide/Azathioprine: Protocol for a Randomized, Double-Blind, Active-Controlled, Phase 3 Trial","year":2020,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Azathioprine; Vasculitis; Anti-neutrophil cytoplasmic antibody; Rituximab; Prednisone; Internal medicine; Immunology; Cyclophosphamide; C5a receptor; Randomized controlled trial; Gastroenterology; Antibody; Disease; Complement system; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004081309,0.0003764313,0.001968123,0.0002352298,0.0002349071,0.00005105345,0.0002427148,0.0002947349,0.0001601139],"category_scores_gemma":[0.002547509,0.0001924495,0.0003500448,0.00151203,0.0007184212,0.0002086765,0.00009760107,0.0008748853,0.000002589333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002583352,"about_ca_system_score_gemma":0.001852108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005835612,"about_ca_topic_score_gemma":0.00002709583,"domain_scores_codex":[0.9930647,0.00203118,0.001383251,0.0006538702,0.002305877,0.0005611419],"domain_scores_gemma":[0.9940727,0.0009986727,0.0008209939,0.0004663188,0.003395075,0.0002462402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.984131,0.008428903,0.001897547,0.0006874198,0.001025147,0.000007887073,0.0005951794,0.00002677044,0.001194149,0.00004644189,0.00008063388,0.001878881],"study_design_scores_gemma":[0.9649788,0.01957038,0.003560338,0.005524564,0.0003595333,0.000004075169,0.00006581716,0.0008445589,0.004258353,0.00001573569,0.0005981179,0.0002197408],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.3956129,0.000002084535,0.00001035548,0.0004367444,0.000004616385,0.6037049,0.0001163206,0.0000232516,0.00008877056],"genre_scores_gemma":[0.1803182,0.000002300211,0.00009525043,0.00001525486,0.00006857871,0.8192812,0.0001159065,0.00005278922,0.00005053491],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.2155762,"threshold_uncertainty_score":0.7847862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09934384377507725,"score_gpt":0.4612189236047359,"score_spread":0.3618750798296587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}