{"id":"W3005550822","doi":"10.1158/1538-7445.sabcs19-p6-08-18","title":"Abstract P6-08-18: Breast cancer in Li-Fraumeni syndrome and risk-reduction mastectomy in <i>TP53</i> p.R337H carriers","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Breast cancer; Penetrance; Genetic counseling; Cancer; Mastectomy; Oncology; Cohort; Population; Internal medicine; Genetic testing; Li–Fraumeni syndrome; Gynecology; Mutation; Germline mutation; Genetics; Environmental health; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002883487,0.0001870765,0.0002497901,0.0004851008,0.0003460851,0.0002307904,0.0001858779,0.0002841019,0.002116477],"category_scores_gemma":[0.001479372,0.000152182,0.0003056795,0.0002930891,0.0002011834,0.0001310427,0.0002355795,0.0002590328,0.0002410999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457495,"about_ca_system_score_gemma":0.0002452745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007653266,"about_ca_topic_score_gemma":0.004261428,"domain_scores_codex":[0.9998791,0.0000290067,0.00001168751,0.0000254734,0.00002333964,0.00003136211],"domain_scores_gemma":[0.9996017,0.00009906304,0.0001362741,0.00003420558,0.00003935656,0.00008939612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004220014,0.0001508508,0.9841527,0.00002618857,0.00002326518,0.007296797,0.0003963254,0.00004053663,0.00243349,0.00004030235,0.0002178211,0.004799644],"study_design_scores_gemma":[0.00003291286,0.0007459127,0.9838832,0.0000237704,0.00003889261,0.01340349,0.0003959928,0.0001587889,0.0004424614,0.00006528845,0.0008016867,0.000007579428],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990975,0.000166843,0.00005749021,0.00004765065,0.000005845101,0.00002348828,0.0001293617,0.000002396892,0.0004695518],"genre_scores_gemma":[0.9994451,0.00009971334,0.00008737205,0.00002507131,0.00000601665,0.000009841953,0.0001090134,0.000001451899,0.000216454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007653266,"threshold_uncertainty_score":0.01521742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05052030731082404,"score_gpt":0.3588827306393811,"score_spread":0.3083624233285571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}