{"id":"W3005574648","doi":"10.1038/s41586-020-2003-8","title":"IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease","year":2020,"lang":"en","type":"article","venue":"Nature","topic":"Celiac Disease Research and Management","field":"Medicine","cited_by":232,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases","keywords":"Coeliac disease; Human leukocyte antigen; Gluten; Immunology; Disease; Medicine; Biology; Pathology; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002493026,0.0001364484,0.0001575795,0.0001540443,0.0001520925,0.0006530396,0.0001321058,0.0003560718,0.001214384],"category_scores_gemma":[0.0003686323,0.0001132502,0.0001326059,0.00007543724,0.000336134,0.0002571967,0.0003970405,0.0005482351,0.0002334626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002671943,"about_ca_system_score_gemma":0.0001703407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002236649,"about_ca_topic_score_gemma":0.0003385555,"domain_scores_codex":[0.9998509,0.00003161787,0.000009741472,0.00002460228,0.00003464347,0.00004843546],"domain_scores_gemma":[0.9998702,0.00002538143,0.000035849,0.000009920032,0.00001541158,0.00004327945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002136865,0.000282452,0.0699926,0.000422408,0.00009019645,0.001590009,0.0005359568,0.0007794801,0.8304717,0.006877245,0.00278009,0.08404092],"study_design_scores_gemma":[0.0006920134,0.004126825,0.5876827,0.0005112992,0.0003339198,0.01016845,0.004138595,0.007290333,0.2696871,0.02166105,0.09363778,0.00006983677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874951,0.007011359,0.0006798137,0.001048183,0.0001567856,0.000007938714,0.00005071262,0.00003517689,0.003514854],"genre_scores_gemma":[0.9969344,0.001049812,0.0003158097,0.000260923,0.00006175311,0.000004799644,0.00002283476,0.000004074314,0.001345502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214384,"threshold_uncertainty_score":0.004062533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008496842310117866,"score_gpt":0.2943922745765317,"score_spread":0.2858954322664138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}