{"id":"W3005590688","doi":"10.1016/j.jmb.2020.01.038","title":"Elongation Factor Tu Switch I Element is a Gate for Aminoacyl-tRNA Selection","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Lethbridge","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Science Foundation","keywords":"Transfer RNA; Aminoacyl-tRNA; EF-Tu; Guanosine; Pseudoknot; T arm; Guanosine triphosphate; Chemistry; Proofreading; Biology; Biochemistry; RNA; Nucleotide; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003445134,0.0003412802,0.0005123038,0.0002894933,0.0005119382,0.001062106,0.0004338345,0.0006040924,0.003089927],"category_scores_gemma":[0.0007190933,0.0002937442,0.0002571243,0.0001468397,0.0005512115,0.0006221436,0.0004337254,0.0008506164,0.001183502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004840403,"about_ca_system_score_gemma":0.0002820658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000286622,"about_ca_topic_score_gemma":0.0004414435,"domain_scores_codex":[0.9998221,0.00002683096,0.00001107876,0.00005170058,0.00004354032,0.00004479918],"domain_scores_gemma":[0.9995983,0.0001626281,0.00005713535,0.00003424871,0.00003467222,0.0001130917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003493103,0.00001681134,0.0003876959,0.00002946245,0.000007239949,0.0003511785,0.00004414945,0.0003090138,0.9901385,0.004625865,0.0002313501,0.003509483],"study_design_scores_gemma":[0.00005389015,0.000204165,0.001938531,0.00001242285,0.00001438006,0.0003233234,0.00007682128,0.004756808,0.9871213,0.002126498,0.003350051,0.00002195232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712631,0.0009403373,0.01817398,0.0005446312,0.0005327236,0.0000271788,0.0001346007,0.0008792707,0.007504114],"genre_scores_gemma":[0.9962173,0.0001295101,0.001995971,0.0001023793,0.00004542556,0.000007125902,0.00007057234,0.00006209164,0.001369699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003089927,"threshold_uncertainty_score":0.01033688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01795100643564923,"score_gpt":0.2797605924921949,"score_spread":0.2618095860565457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}