{"id":"W3005606578","doi":"10.1101/2020.02.13.948125","title":"The LUBAC participates in Lysophosphatidic Acid-induced NF-κB Activation","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Direction Générale de l’offre de Soins; Institut National Du Cancer; Conseil Régional des Pays de la Loire; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"Cell biology; G protein-coupled receptor; Signal transducing adaptor protein; Signal transduction; Guanine nucleotide exchange factor; Lysophosphatidic acid; Scaffold protein; Receptor; TRAF2; Transcription factor; Chemistry; NF-κB; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002466398,0.0008223558,0.0003410212,0.0005153079,0.0005954525,0.0004973907,0.0002056079,0.0005801011,0.00314029],"category_scores_gemma":[0.0002104205,0.0001661493,0.0006173198,0.0002031878,0.0003161067,0.0003911061,0.0004944575,0.0006495376,0.001337121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003702595,"about_ca_system_score_gemma":0.0002157846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003356338,"about_ca_topic_score_gemma":0.0002917921,"domain_scores_codex":[0.9997588,0.0000441761,0.00002058574,0.00004231686,0.00004901586,0.00008510084],"domain_scores_gemma":[0.9997806,0.00001741143,0.00006577544,0.00001725466,0.00003779043,0.0000811636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009914301,0.00005929255,0.0008929638,0.0003875383,0.00003303935,0.0003916667,0.0000490331,0.0000813263,0.9946877,0.0003921229,0.0002171574,0.001816677],"study_design_scores_gemma":[0.0001381524,0.0003634972,0.02088013,0.00007933834,0.00008952874,0.001716044,0.0002214552,0.001919825,0.9617537,0.0006957198,0.01211481,0.00002776213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968854,0.02092635,0.005720559,0.0004746383,0.0002443706,0.00008933862,0.001064523,0.0001913812,0.002434846],"genre_scores_gemma":[0.9912587,0.002135258,0.002020139,0.00010467,0.00005414509,0.00005669012,0.001042613,0.00002658224,0.0033012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00314029,"threshold_uncertainty_score":0.01050538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02079441184680513,"score_gpt":0.2393477177888468,"score_spread":0.2185533059420417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}