{"id":"W3005626512","doi":"10.1097/pai.0000000000000838","title":"Problems With the Recommendations for PD-L1 Biomarker Testing","year":2020,"lang":"en","type":"letter","venue":"Applied immunohistochemistry & molecular morphology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lions Gate Hospital","funders":"","keywords":"Biomarker; Immunohistochemistry; Internal medicine; Computer science; Medicine; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0254066,0.0009427803,0.00157407,0.002669426,0.004286034,0.004756046,0.005056161,0.05687393,0.007230182],"category_scores_gemma":[0.1548058,0.001614591,0.00275901,0.001854838,0.007237189,0.008252453,0.002907155,0.06879696,0.01492668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006436672,"about_ca_system_score_gemma":0.006597268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005296695,"about_ca_topic_score_gemma":0.007693083,"domain_scores_codex":[0.9730633,0.008617246,0.005593643,0.00246085,0.00900926,0.001255653],"domain_scores_gemma":[0.9112061,0.04868903,0.00282489,0.003529596,0.02844385,0.005306453],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002630016,0.00003658505,0.0007153664,0.00007186647,0.00001311518,0.001509621,0.000115289,0.0001505226,0.0001557268,0.004921689,0.9687039,0.02357993],"study_design_scores_gemma":[0.0000972386,0.00007310872,0.001165721,0.0008210695,0.00003786513,0.009083143,0.0003064519,0.001096333,0.0003258406,0.03927115,0.9476053,0.0001167962],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001508796,0.001037487,0.0004186072,0.9843169,0.01173833,0.00001241212,0.00003639628,0.00004941461,0.002239472],"genre_scores_gemma":[0.003095506,0.00176212,0.002362858,0.9439232,0.04578514,0.00008372014,0.00007594449,0.00005764278,0.002853849],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9745934,"threshold_uncertainty_score":0.1343645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03156108046655366,"score_gpt":0.2763760807947559,"score_spread":0.2448150003282022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}