{"id":"W3005643883","doi":"10.1097/01.hs9.0000561572.20578.17","title":"S823 RANDOMIZED, OPEN‐LABEL, NON‐INFERIORITY, PHASE 3 STUDY OF SUBCUTANEOUS (SC) VERSUS INTRAVENOUS (IV) DARATUMUMAB (DARA) ADMINISTRATION IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA: COLUMBA","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Clinical endpoint; Neutropenia; Refractory (planetary science); Multiple myeloma; Population; Daratumumab; Phases of clinical research; Gastroenterology; Randomized controlled trial; Surgery; Lenalidomide; Clinical trial; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003992226,0.0004130429,0.001497716,0.0001333282,0.0001243644,0.00007914349,0.0003205888,0.0001987628,0.00078523],"category_scores_gemma":[0.0004924319,0.0003048829,0.00007864065,0.00049063,0.0001428519,0.0002986306,0.0001691593,0.0004841709,0.000104575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003501999,"about_ca_system_score_gemma":0.00080805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001368811,"about_ca_topic_score_gemma":0.006917951,"domain_scores_codex":[0.9965792,0.0003145501,0.0008377772,0.0007036256,0.0009900912,0.0005747319],"domain_scores_gemma":[0.9974426,0.0005966442,0.0003798118,0.0008742277,0.0003850042,0.0003217228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8285289,0.02744186,0.1311497,0.00022989,0.0006534196,0.001902039,0.0009234131,0.000005627941,0.0003726974,0.000007549454,0.00009479291,0.008690124],"study_design_scores_gemma":[0.8775768,0.06829334,0.05058559,0.0003231239,0.0002673282,0.00004402029,0.001212755,0.0007639211,0.0004681584,0.000003817342,0.0001172893,0.0003439021],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854378,0.00007524416,0.000009928961,0.00002915218,0.0002411254,0.0110826,0.00006729085,0.00004367646,0.003013191],"genre_scores_gemma":[0.9969803,0.00002322356,0.0007500316,0.0000172125,0.00003842112,0.0003415141,0.0003079512,0.00007156598,0.001469771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0805641,"threshold_uncertainty_score":0.9999403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0321007392232158,"score_gpt":0.3338785845535127,"score_spread":0.3017778453302969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}