{"id":"W3005643883","doi":"10.1097/01.hs9.0000561572.20578.17","title":"S823 RANDOMIZED, OPEN‐LABEL, NON‐INFERIORITY, PHASE 3 STUDY OF SUBCUTANEOUS (SC) VERSUS INTRAVENOUS (IV) DARATUMUMAB (DARA) ADMINISTRATION IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA: COLUMBA","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Clinical endpoint; Neutropenia; Refractory (planetary science); Multiple myeloma; Population; Daratumumab; Phases of clinical research; Gastroenterology; Randomized controlled trial; Surgery; Lenalidomide; Clinical trial; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003323873,0.001745156,0.00252289,0.0005227826,0.0006966896,0.001787112,0.001273833,0.001868299,0.01464395],"category_scores_gemma":[0.001611296,0.0010835,0.001902599,0.0006945163,0.001481962,0.001205262,0.0005337832,0.004474862,0.002351917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001681206,"about_ca_system_score_gemma":0.003573374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002346653,"about_ca_topic_score_gemma":0.007700601,"domain_scores_codex":[0.9990895,0.0005549898,0.00002732851,0.0001293009,0.00006045416,0.000138504],"domain_scores_gemma":[0.9987745,0.0002699526,0.0002606556,0.00009626797,0.00008782837,0.0005107439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9636417,0.01512255,0.000920193,0.0003591667,0.0005918081,0.00006297455,0.0001148862,0.000448014,0.007618374,0.0001230663,0.002024264,0.00897294],"study_design_scores_gemma":[0.9407328,0.05524926,0.001994243,0.00001703688,0.0001656109,0.0000370834,0.00002429983,0.0004057163,0.0002754802,0.00008131934,0.0010052,0.00001197409],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804431,0.002225996,0.0009779788,0.001188646,0.0004884644,0.008692483,0.002567121,0.0002666755,0.003149592],"genre_scores_gemma":[0.9789083,0.001157894,0.001809828,0.001643988,0.0003421107,0.008110443,0.00195755,0.00006804796,0.006001726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01464395,"threshold_uncertainty_score":0.04898888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0321007392232158,"score_gpt":0.3338785845535127,"score_spread":0.3017778453302969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}