{"id":"W3005675525","doi":"10.1111/adb.12880","title":"Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies","year":2020,"lang":"en","type":"article","venue":"Addiction Biology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hospital for Sick Children; St. Joseph’s Healthcare Hamilton; University of Toronto; University Health Network; Centre for Addiction and Mental Health","funders":"Cilag; North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Seqirus; Mitsubishi Tanabe Pharma Corporation; Servier; Genesis Pharma; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National and Kapodistrian University of Athens; Bundesministerium für Bildung und Forschung; King's College London; National Center for Advancing Translational Sciences; Medical Research Council; Teva Pharmaceutical Industries; Department of Health and Social Care; American Society of Clinical Psychopharmacology; National Institute of Mental Health; Avanir Pharmaceuticals; Maudsley Charity; Jazz Pharmaceuticals; Wellcome Trust; Lilly Deutschland; Vrije Universiteit Amsterdam; National Institute of General Medical Sciences; H. Lundbeck A/S; Sunovion; National Institute for Health and Care Research; Lundbeckfonden; Eli Lilly and Company; Assurex Health; Louis and Harold Price Foundation; Deutsche Forschungsgemeinschaft; Mayo Foundation for Medical Education and Research; Indivior; Sanofi; Pfizer; Robert Bosch Stiftung; GlaxoSmithKline; AstraZeneca; Bristol-Myers Squibb","keywords":"Genome-wide association study; Genetic association; Phenotype; Association (psychology); Substance use; Psychology; Clinical psychology; Psychiatry; Genetics; Medicine; Biology; Gene; Psychotherapist; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003300195,0.000203754,0.0003642766,0.00003466587,0.0002312159,0.00002081722,0.0001328923,0.0004023919,0.00005660981],"category_scores_gemma":[0.00664053,0.0001975138,0.00008010321,0.000151469,0.00008905776,0.00001280739,0.0001110854,0.0001944807,0.00003099322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006275977,"about_ca_system_score_gemma":0.00003286374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003280834,"about_ca_topic_score_gemma":0.0002576951,"domain_scores_codex":[0.9979874,0.0005143426,0.0005035159,0.0006119733,0.00007579342,0.0003070115],"domain_scores_gemma":[0.9979088,0.001124012,0.0005038013,0.000194965,0.0001620284,0.0001063704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002476125,0.000007573695,0.988431,0.000003906153,0.0005267905,3.699307e-7,0.0004518337,0.0002607504,0.006993493,0.000003046295,0.0008602994,0.002436155],"study_design_scores_gemma":[0.0004655694,0.0003393099,0.9922282,0.0000163773,0.0001619842,5.078025e-7,0.0002547632,0.0003723061,0.0001797145,0.0004973877,0.005271084,0.000212822],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778448,0.01499133,0.004768762,0.001645982,0.0001624948,0.0002105593,0.0003049056,0.0000437069,0.00002743371],"genre_scores_gemma":[0.9861616,0.008800345,0.003053831,0.0007473753,0.0003718913,0.00003678582,0.0007346547,0.00002163395,0.00007183819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00831682,"threshold_uncertainty_score":0.8054377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03376287658898915,"score_gpt":0.2755650061182484,"score_spread":0.2418021295292592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}