{"id":"W3005689833","doi":"10.1093/cid/ciaa144","title":"Evaluation of Sustained Virologic Response as a Relevant Surrogate Endpoint for Long-term Outcomes of Hepatitis C Virus Infection","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Hazard ratio; Confidence interval; Liver transplantation; Surrogate endpoint; Clinical endpoint; Gastroenterology; Hepatitis C; Hepatocellular carcinoma; Cirrhosis; Clinical trial; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0507092,0.0007678366,0.001072317,0.001201178,0.0003184258,0.001538139,0.0008182969,0.0005523257,0.001385734],"category_scores_gemma":[0.0489787,0.0001289819,0.001588724,0.001244002,0.0009983263,0.001112184,0.0009372039,0.001470633,0.0002054049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007958827,"about_ca_system_score_gemma":0.001259935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002563379,"about_ca_topic_score_gemma":0.0004301184,"domain_scores_codex":[0.9713258,0.0234337,0.001417532,0.0008911689,0.002634086,0.0002977482],"domain_scores_gemma":[0.9272776,0.04170982,0.02271308,0.003285279,0.003311109,0.001703137],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02311487,0.0006961245,0.8965963,0.001310641,0.00503038,0.0001229144,0.0003386088,0.006033218,0.001266378,0.00294832,0.00132847,0.06121378],"study_design_scores_gemma":[0.001218832,0.02935198,0.907454,0.000916703,0.003388145,0.001013647,0.0004739682,0.03705112,0.003719438,0.00813862,0.007136207,0.0001374385],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9508169,0.01259602,0.02508642,0.001409557,0.0002813995,0.0006234701,0.003033344,0.00005997207,0.00609295],"genre_scores_gemma":[0.9951035,0.0005185683,0.00283919,0.000137415,0.0001165631,0.0003323321,0.000705124,0.00001035258,0.0002368556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9492908,"threshold_uncertainty_score":0.2681791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1680050200510556,"score_gpt":0.4776755941761908,"score_spread":0.3096705741251352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}