{"id":"W3005718707","doi":"10.1016/j.jmb.2020.01.041","title":"Carbohydrate-Binding Capability and Functional Conformational Changes of AbnE, an Arabino-oligosaccharide Binding Protein","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"H2020 European Research Council; Israeli Centers for Research Excellence; European Research Council; Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology; Technion-Israel Institute of Technology; Ministry of Science and Technology, Israel; Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion-Israel Institute of Technology; Azrieli Foundation; Horizon 2020 Framework Programme; Leona M. and Harry B. Helmsley Charitable Trust; Ministry of Science and Technology; Israel Science Foundation; Seventh Framework Programme; Weizmann Institute of Science; Ministry of Environmental Protection; Nancy and Stephen Grand Technion Energy Program; European Synchrotron Radiation Facility","keywords":"Isothermal titration calorimetry; ATP-binding cassette transporter; Chemistry; Oligosaccharide; Geobacillus stearothermophilus; Biochemistry; Thermophile; Transmembrane protein; Mutagenesis; Nucleotide sugar; Crystallography; Biophysics; Biology; Enzyme; Biosynthesis; Transporter; Mutant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152186,0.0001648188,0.00009673351,0.000121156,0.0001435572,0.0001690641,0.0002301582,0.0001624388,0.001798002],"category_scores_gemma":[0.0002116828,0.00009282929,0.0001627352,0.0001299812,0.0002205695,0.0002020096,0.0001143896,0.0003750104,0.0002624134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060337,"about_ca_system_score_gemma":0.0001289435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085312,"about_ca_topic_score_gemma":0.0007283366,"domain_scores_codex":[0.9999363,0.00001064062,0.000004559808,0.00001406359,0.00001366819,0.00002065601],"domain_scores_gemma":[0.9998419,0.00005218628,0.00001893613,0.00001445262,0.00001903466,0.00005341304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002221448,0.00004508921,0.0002692116,0.000009102725,0.000003914347,0.00004150415,0.0000184459,0.00005711487,0.9988513,0.0001166005,0.00001289863,0.0003526191],"study_design_scores_gemma":[0.00001888463,0.0001749246,0.01429438,0.000002921726,0.0000108795,0.0002808551,0.00004397126,0.001792258,0.9824421,0.0000777524,0.0008527366,0.000008382905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992706,0.00007408829,0.0002808626,0.00001622059,0.00000426843,0.000001804401,0.00006207381,0.000002992351,0.0002870417],"genre_scores_gemma":[0.9982426,0.00004480881,0.0002190322,0.00001673913,0.000002838182,0.000002925512,0.0003773503,0.000004958712,0.001088711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798002,"threshold_uncertainty_score":0.006014943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01569466387975135,"score_gpt":0.2413653843985289,"score_spread":0.2256707205187775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}