{"id":"W3005789657","doi":"10.1038/s41589-020-0481-5","title":"Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis","year":2020,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Depsipeptide; Nonribosomal peptide; Chemistry; Computational biology; Biochemistry; Combinatorial chemistry; Stereochemistry; Biology; Biosynthesis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007736771,0.0001715887,0.0002551342,0.00003817356,0.00001652743,0.000005121553,0.0003432139,0.0009248892,0.00007330759],"category_scores_gemma":[0.001140388,0.000146771,0.0001098801,0.000220663,0.0001920682,0.000002709008,0.0002395834,0.0004318297,0.000005688318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001350254,"about_ca_system_score_gemma":0.00005145642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008861746,"about_ca_topic_score_gemma":0.000005836159,"domain_scores_codex":[0.9987578,0.0000798833,0.0002604557,0.0004782851,0.0001148783,0.0003086544],"domain_scores_gemma":[0.9994554,0.00003523986,0.00006320771,0.0002085113,0.00009513603,0.0001424925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002934712,0.00002658471,0.004484069,0.00004000582,0.00002808328,0.00000318423,0.00001101438,9.375888e-7,0.9899605,0.0001917304,0.0004254918,0.004534965],"study_design_scores_gemma":[0.0003562677,0.000107881,0.0006721482,0.00001003512,0.000008894326,0.000006323258,0.00001215442,0.00007407454,0.9949654,0.00009535588,0.003534269,0.0001571453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961174,0.001820979,0.0001291862,0.001099122,0.00004231949,0.0001357374,0.00006648981,0.00001162094,0.0005771542],"genre_scores_gemma":[0.9975623,0.00009532311,0.0008241655,0.0009081759,0.0001690273,0.0000178535,0.0003977158,0.00001716392,0.00000828594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005004989,"threshold_uncertainty_score":0.7133593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02099369322738914,"score_gpt":0.2963429264161878,"score_spread":0.2753492331887987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}