{"id":"W3005827157","doi":"10.1158/1538-7445.sabcs19-p3-06-10","title":"Abstract P3-06-10: Temozolomide & vorinostat as a targeted therapy strategy for triple negative breast cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Health Services","funders":"","keywords":"Temozolomide; Triple-negative breast cancer; Vorinostat; Cancer research; PARP inhibitor; Breast cancer; Medicine; Cisplatin; Combination therapy; Decitabine; Oncology; Cancer; Internal medicine; Chemotherapy; DNA methylation; Histone deacetylase; Biology; Glioma; Histone; Poly ADP ribose polymerase; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223213,0.0003027828,0.0002892064,0.0003150901,0.0001598973,0.0003844931,0.0003011548,0.0003202891,0.01099336],"category_scores_gemma":[0.00006853943,0.00006619371,0.0002749982,0.000247803,0.000121667,0.0002196646,0.0002286865,0.0008755432,0.003185416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004254072,"about_ca_system_score_gemma":0.0003611856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007529979,"about_ca_topic_score_gemma":0.001712352,"domain_scores_codex":[0.9999624,0.000005471182,0.000002487991,0.00000658676,0.00001249341,0.00001050972],"domain_scores_gemma":[0.9999677,0.000002210737,0.000004965822,0.000001892025,0.000006964643,0.00001624686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004569631,0.001871602,0.001077116,0.001575981,0.0001228772,0.001029686,0.00004436806,0.0007724785,0.2325562,0.002512317,0.06215548,0.6917124],"study_design_scores_gemma":[0.005019038,0.0211649,0.02220924,0.0006892322,0.0004653276,0.008900018,0.0001063198,0.004544354,0.3475128,0.001737424,0.5875736,0.00007767784],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5428282,0.2899968,0.009551411,0.01157726,0.004176303,0.001525514,0.007962395,0.001932775,0.1304492],"genre_scores_gemma":[0.8392091,0.086753,0.007815544,0.003097533,0.0007684328,0.0004428324,0.006551848,0.000130165,0.05523156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01099336,"threshold_uncertainty_score":0.03677648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1017129433791745,"score_gpt":0.4234248725733687,"score_spread":0.3217119291941943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}