{"id":"W3005898841","doi":"10.1016/j.clcc.2020.02.001","title":"Integration of Whole-Genome Sequencing With Circulating Tumor DNA Analysis Captures Clonal Evolution and Tumor Heterogeneity in Non-V600 BRAF Mutant Colorectal Cancer","year":2020,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Pancreas Centre (Canada); BC Cancer Agency; Simon Fraser University","funders":"National Center for Advancing Translational Sciences; Genome British Columbia; BC Cancer Foundation; National Institutes of Health; Michael Smith Health Research BC; Genome Canada","keywords":"Mutation; Cancer research; Colorectal cancer; V600E; Kinase; Mutant; Epidermal growth factor receptor; Oncogene; Biology; Protein kinase A; c-Raf; Cancer; Medicine; Genetics; Mitogen-activated protein kinase kinase; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003231622,0.0001445944,0.0001972452,0.0005645442,0.0001493234,0.0004714286,0.0001839462,0.0003264703,0.0009413227],"category_scores_gemma":[0.001416273,0.0001602112,0.0001329263,0.0003710662,0.0001458544,0.0002772242,0.0002170741,0.000330589,0.0001669801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002509649,"about_ca_system_score_gemma":0.0001964899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001887212,"about_ca_topic_score_gemma":0.006076949,"domain_scores_codex":[0.9998203,0.00002949631,0.000006880938,0.00006361804,0.00004865276,0.00003107728],"domain_scores_gemma":[0.9995173,0.0002146391,0.00008940852,0.00004097006,0.00007762719,0.00006009724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000680551,0.0001081273,0.3054404,0.000112814,0.0001376817,0.0002513879,0.0002541133,0.002279155,0.6179131,0.0005270273,0.0009188981,0.07137673],"study_design_scores_gemma":[0.00003352375,0.000413269,0.8699299,0.00002626205,0.0001693883,0.001957037,0.0003151187,0.03054398,0.09123818,0.001050796,0.004301223,0.0000213613],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952984,0.0004124122,0.003077644,0.00006957286,0.00001062399,0.000008776487,0.0003918349,0.00006151676,0.0006690428],"genre_scores_gemma":[0.9957426,0.0001197831,0.003110406,0.00006583408,0.00001066012,0.00000860703,0.0004421225,0.00002522187,0.0004746432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887212,"threshold_uncertainty_score":0.00375241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04697987202862499,"score_gpt":0.3459465507992645,"score_spread":0.2989666787706395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}