{"id":"W3005905327","doi":"10.1038/s41588-019-0575-8","title":"A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo","year":2020,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":147,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; SickKids Foundation; Université Laval; Hospital for Sick Children","funders":"National Institute of Environmental Health Sciences; National Human Genome Research Institute; Cancer Research UK","keywords":"Trinucleotide repeat expansion; Biology; DNA; Striatum; Mutant; Huntington's disease; In vivo; Transcription (linguistics); DNA repair; DNA replication; Cell biology; Genetics; Molecular biology; Transcription factor; Allele; Gene; Internal medicine; Endocrinology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003759509,0.0003984618,0.0003520254,0.0002868163,0.0002149173,0.0002620831,0.0004144491,0.0005409649,0.002732275],"category_scores_gemma":[0.0002745667,0.0002930997,0.0002750839,0.0001386229,0.0003557111,0.0001464089,0.0003349019,0.0009142917,0.0006023332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003323548,"about_ca_system_score_gemma":0.0002875109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006456018,"about_ca_topic_score_gemma":0.001032955,"domain_scores_codex":[0.9997888,0.00004191196,0.00001468079,0.000063497,0.00004802027,0.00004313291],"domain_scores_gemma":[0.9995313,0.0001986493,0.00008784422,0.00005360687,0.00001863601,0.0001100397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006917035,0.00002066238,0.00003125537,0.00000800873,0.000003128339,0.00002388702,0.000004088002,0.00002605134,0.9994598,0.00004522911,0.00002182703,0.0002868421],"study_design_scores_gemma":[0.00002983587,0.0002661198,0.0008967969,0.000003254078,0.000005761238,0.0001124066,0.000006508588,0.0006610648,0.9972416,0.00002564594,0.0007476622,0.000003289449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920108,0.0007548082,0.004243224,0.0001352476,0.00008640579,0.00005459757,0.0001775774,0.0001633697,0.002373919],"genre_scores_gemma":[0.9902429,0.0004084769,0.004136946,0.0001242013,0.0000316156,0.00007380118,0.0007179338,0.0001186536,0.00414547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002732275,"threshold_uncertainty_score":0.009140372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03531100015798447,"score_gpt":0.2762495722802551,"score_spread":0.2409385721222706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}