{"id":"W3005908190","doi":"10.1158/1538-7445.sabcs19-gs1-01","title":"Abstract GS1-01: Tucatinib vs placebo, both combined with capecitabine and trastuzumab, for patients with pretreated HER2-positive metastatic breast cancer with and without brain metastases (HER2CLIMB)","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Capecitabine; Medicine; Trastuzumab; Metastatic breast cancer; Internal medicine; Clinical endpoint; Oncology; Pertuzumab; Breast cancer; Neratinib; Regimen; Palbociclib; Cancer; Clinical trial; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001822373,0.002239168,0.003495012,0.0009976232,0.0004083733,0.001664758,0.001269489,0.002604824,0.01390161],"category_scores_gemma":[0.001924341,0.0007814301,0.002697782,0.0006073589,0.001670082,0.001720257,0.0006428699,0.004259523,0.001685539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001160821,"about_ca_system_score_gemma":0.001547093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242568,"about_ca_topic_score_gemma":0.002719547,"domain_scores_codex":[0.9990885,0.0004769485,0.00005809109,0.0001446275,0.00005257334,0.0001792283],"domain_scores_gemma":[0.9988365,0.0003252504,0.0002193892,0.00006382963,0.00005198055,0.0005029651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9843583,0.005109267,0.000170182,0.0002545473,0.0003365065,0.00001574235,0.00002044144,0.0002371944,0.001454829,0.0000706625,0.000483376,0.007488866],"study_design_scores_gemma":[0.8236243,0.1730145,0.001406167,0.00003073863,0.0003971411,0.00002481359,0.00002225761,0.0003960379,0.0004974197,0.000150089,0.0004206372,0.00001596689],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870228,0.003066187,0.0003362179,0.001035272,0.0009266168,0.002765251,0.001605236,0.000217418,0.00302509],"genre_scores_gemma":[0.9887952,0.001608937,0.0006486036,0.001029374,0.0006069756,0.001943176,0.001299839,0.00002357044,0.004044363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01390161,"threshold_uncertainty_score":0.04650557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04827342277203703,"score_gpt":0.3868982683123232,"score_spread":0.3386248455402861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}