{"id":"W3005910897","doi":"10.1016/j.jaad.2020.02.009","title":"Effects of ruxolitinib cream on pruritus and quality of life in atopic dermatitis: Results from a phase 2, randomized, dose-ranging, vehicle- and active-controlled study","year":2020,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Janssen Biotech; Genentech; Bausch Health; MedImmune; Sanofi; Kyowa Hakko Kirin; InflaRx; Pfizer; Incyte; Dermira; Astellas Pharma Canada; Coherus Biosciences; Valeant Pharmaceuticals International; Galderma; UCB; Regeneron Pharmaceuticals; Novartis; Celgene; LEO Pharma; Gilead Sciences; GlaxoSmithKline; Merck; Roche; Baxalta; AbbVie; Genzyme; Amgen; Meiji Seika Pharma; Bristol-Myers Squibb","keywords":"Medicine; Atopic dermatitis; Dose-ranging study; Ruxolitinib; Randomized controlled trial; Dermatology; Quality of life (healthcare); Internal medicine; Alternative medicine; Double blind","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002581858,0.001200902,0.002920307,0.0004619364,0.0003527321,0.0007552059,0.0007816077,0.001261546,0.002864221],"category_scores_gemma":[0.001363561,0.0005140469,0.00169294,0.0003970613,0.0007749407,0.0007155986,0.000231804,0.001939177,0.0005063294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005184922,"about_ca_system_score_gemma":0.0006327936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005000241,"about_ca_topic_score_gemma":0.001069171,"domain_scores_codex":[0.9991783,0.0004500877,0.00006288308,0.0001013758,0.0000946966,0.0001125649],"domain_scores_gemma":[0.9990118,0.0003551741,0.0002419701,0.00008238125,0.00007875971,0.0002300025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.889176,0.03163922,0.002405926,0.001675247,0.002049157,0.0001144725,0.00009639465,0.0005637324,0.0149001,0.00006332873,0.001027625,0.05628881],"study_design_scores_gemma":[0.8535478,0.1350149,0.008212893,0.00004324703,0.0008818742,0.00008827661,0.00002307472,0.000421841,0.001179109,0.00004075302,0.0005303054,0.00001591084],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886338,0.007835443,0.0003647292,0.0002230384,0.0001469946,0.001447628,0.0005369377,0.00007151021,0.0007398798],"genre_scores_gemma":[0.9907916,0.004515503,0.0008130003,0.0005156003,0.0003087803,0.001546029,0.0007018731,0.00001608995,0.000791594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002920307,"threshold_uncertainty_score":0.01365435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069198284076659,"score_gpt":0.331547145434567,"score_spread":0.3108551625938004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}