{"id":"W3005927876","doi":"10.1126/scitranslmed.aax1337","title":"Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice","year":2020,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Neurotoxicity; Pharmacology; Bilirubin; Medicine; Neuroscience; Chemistry; Internal medicine; Biology; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003806456,0.0005951911,0.0004624678,0.0006173537,0.0001909845,0.0004246153,0.0004060763,0.0004967639,0.001989058],"category_scores_gemma":[0.0002171234,0.000270881,0.0003905337,0.0002818741,0.0006206772,0.0005847836,0.0003444403,0.001260493,0.0002959165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000534663,"about_ca_system_score_gemma":0.0004986675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007764594,"about_ca_topic_score_gemma":0.001623022,"domain_scores_codex":[0.9997043,0.00004848058,0.0000388981,0.00005804302,0.00006751279,0.00008271595],"domain_scores_gemma":[0.9996959,0.0000197049,0.0001150138,0.00002570447,0.00003093182,0.0001127834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009194515,0.00009530182,0.0004314278,0.00007046517,0.00001557443,0.00007892086,0.00003731158,0.0001426067,0.9956089,0.0002936276,0.0001345795,0.002171964],"study_design_scores_gemma":[0.00007356238,0.001168362,0.005784383,0.00002212092,0.00005528916,0.0002649628,0.00008455422,0.001238201,0.9891333,0.0002567603,0.001906384,0.00001201342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903092,0.001791738,0.004748201,0.0004414853,0.0001078926,0.00005417696,0.0006685915,0.0002996678,0.001579135],"genre_scores_gemma":[0.990553,0.001517968,0.002512639,0.0002365486,0.00002603791,0.0001262344,0.0004134541,0.00006289657,0.004551116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001989058,"threshold_uncertainty_score":0.006654084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03781610136442567,"score_gpt":0.3265890158060955,"score_spread":0.2887729144416699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}