{"id":"W3005931313","doi":"10.1111/all.14235","title":"Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma","year":2020,"lang":"en","type":"review","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; SickKids Foundation; Hospital for Sick Children; McMaster University; University of Toronto","funders":"European Academy of Allergy and Clinical Immunology","keywords":"Benralizumab; Medicine; Omalizumab; Dupilumab; Asthma; Dermatology; Allergy; Intensive care medicine; Immunology; Mepolizumab; Immunoglobulin E; Antibody; Eosinophil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004822821,0.0006133146,0.003703768,0.00009503162,0.0001470145,0.0000203254,0.0002317942,0.0002500668,0.00006283027],"category_scores_gemma":[0.00179846,0.0002237141,0.0005827185,0.0002993912,0.0002405003,0.0000386144,0.00009469182,0.0001476816,0.000001532049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009386397,"about_ca_system_score_gemma":0.0002931005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002405145,"about_ca_topic_score_gemma":0.00004154139,"domain_scores_codex":[0.9965298,0.0006458309,0.001783412,0.0005917383,0.0001692281,0.0002800548],"domain_scores_gemma":[0.9925231,0.005324102,0.001126255,0.0006344215,0.0002566729,0.0001354629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001709498,0.0005536224,0.000006837091,0.4180292,0.003452269,0.00002211393,0.0001042099,0.00002399094,0.000001055027,0.001519242,0.004894062,0.5696839],"study_design_scores_gemma":[0.002023803,0.004173298,0.0000261385,0.1957976,0.001300118,0.0001211307,0.00008021632,0.0000518286,3.387826e-7,0.00001212094,0.7961829,0.0002304227],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001357312,0.9826635,0.00007054902,0.003393396,0.0000321765,0.01278689,0.0008773205,0.00002269185,0.00001772125],"genre_scores_gemma":[0.0001993059,0.9948821,0.000687392,0.0009781786,0.0000625679,0.002621373,0.0003825693,0.00004476317,0.0001417636],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7912889,"threshold_uncertainty_score":0.9122797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1619236632582277,"score_gpt":0.3718014890064571,"score_spread":0.2098778257482294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}