{"id":"W3005943381","doi":"10.1007/s43440-019-00045-6","title":"The synthetic oleanane triterpenoid CDDO-Me binds and inhibits pyruvate kinase M2","year":2020,"lang":"en","type":"article","venue":"Pharmacological Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"PKM2; Pyruvate kinase; Chemistry; Warburg effect; Gene knockdown; Cell culture; Cell migration; Cell biology; Biochemistry; Glycolysis; Cell; Biology; Enzyme; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009971661,0.0002263383,0.0002090417,0.0001950737,0.0001630073,0.0002633606,0.0002423761,0.000183304,0.00221836],"category_scores_gemma":[0.00009679865,0.0001122781,0.0001216548,0.0001577499,0.0002456499,0.0001753898,0.0001865981,0.0004777407,0.0005201555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002666296,"about_ca_system_score_gemma":0.0002138953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006450569,"about_ca_topic_score_gemma":0.00132979,"domain_scores_codex":[0.99994,0.000007762606,0.000003888096,0.00001123458,0.00001270299,0.0000242882],"domain_scores_gemma":[0.9999492,0.00001305911,0.00000905065,0.000007725315,0.000004866366,0.00001600423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000244622,0.00002907362,0.00007697503,0.00003404858,0.000005453906,0.00002232185,0.00001206225,0.00005681264,0.9974945,0.0001659311,0.00009357142,0.001764675],"study_design_scores_gemma":[0.00002835412,0.00018983,0.000593208,0.000002434875,0.000005331103,0.00005053371,0.00001870229,0.0001571396,0.9959742,0.00002966511,0.002948351,0.000002181451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852432,0.004289959,0.003962103,0.0004084681,0.0001054324,0.00004714574,0.0003784372,0.0001399902,0.005425252],"genre_scores_gemma":[0.9908944,0.001998652,0.001398472,0.0001264548,0.00002131899,0.00002547192,0.0004742783,0.00001595297,0.005045124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00221836,"threshold_uncertainty_score":0.007421196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854747444321936,"score_gpt":0.2761696192535141,"score_spread":0.2576221448102948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}