{"id":"W3005955238","doi":"10.1001/jama.2020.0103","title":"Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia","year":2020,"lang":"en","type":"article","venue":"JAMA","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":275,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medicine and Health, University of Sydney; National Medical Research Council; Sanofi Pasteur; Genentech; Duke Clinical Research Institute; NSW Ministry of Health; Astellas Pharma; Basilea Pharmaceutica; Galderma; Institute of Infection and Immunity; National Health and Medical Research Council; Allergan; Regeneron Pharmaceuticals; National Institutes of Health; Shionogi; Pfizer Australia; Singapore General Hospital; Royal Adelaide Hospital; Monash University; Wockhardt; NSW Health Pathology; Sanofi; Medical Research Council; Menzies School of Health Research; University of Notre Dame; Fiona Stanley Hospital; Pfizer; Johns Hopkins University; University of Queensland; Duke-NUS Medical School","keywords":"Medicine; Bacteremia; Daptomycin; Flucloxacillin; Vancomycin; Internal medicine; Randomized controlled trial; Clinical endpoint; Cefazolin; Intravenous therapy; Surgery; Antibiotics; Staphylococcus aureus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001636995,0.0004791176,0.0009524144,0.0001350416,0.00004404118,0.00004130758,0.0001680331,0.0001771096,0.0002255912],"category_scores_gemma":[0.00007840402,0.0002496328,0.00008282417,0.0004682645,0.0001139716,0.0001486008,0.00004590986,0.0004175351,0.00001933188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001365996,"about_ca_system_score_gemma":0.0001755294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001140776,"about_ca_topic_score_gemma":0.0003734937,"domain_scores_codex":[0.9978278,0.0001723277,0.0004629357,0.0006127794,0.0005070989,0.0004170537],"domain_scores_gemma":[0.9985371,0.0001564319,0.000230873,0.0005098268,0.0001295109,0.000436293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05806147,0.001336195,0.9280677,0.0004458818,0.0002628492,0.0003538379,0.0004585632,0.0000497289,0.001992854,0.00001074704,0.0004377867,0.008522398],"study_design_scores_gemma":[0.03671089,0.055473,0.8870404,0.0007420633,0.0004401395,0.00000920842,0.00004414044,0.0004125447,0.01716026,4.737352e-7,0.001620503,0.0003464135],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971443,0.000004837542,0.00003999103,0.0005417688,0.00005329587,0.001537702,0.00007835095,0.00006128877,0.0005384802],"genre_scores_gemma":[0.9979842,0.00001564443,0.0008712909,0.0004133167,0.000180267,0.00001229692,0.0002120481,0.00008576791,0.0002251911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0541368,"threshold_uncertainty_score":0.9999956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729142179709693,"score_gpt":0.2973649001022878,"score_spread":0.2800734783051909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}