{"id":"W3005955238","doi":"10.1001/jama.2020.0103","title":"Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia","year":2020,"lang":"en","type":"article","venue":"JAMA","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":275,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medicine and Health, University of Sydney; National Medical Research Council; Sanofi Pasteur; Genentech; Duke Clinical Research Institute; NSW Ministry of Health; Astellas Pharma; Basilea Pharmaceutica; Galderma; Institute of Infection and Immunity; National Health and Medical Research Council; Allergan; Regeneron Pharmaceuticals; National Institutes of Health; Shionogi; Pfizer Australia; Singapore General Hospital; Royal Adelaide Hospital; Monash University; Wockhardt; NSW Health Pathology; Sanofi; Medical Research Council; Menzies School of Health Research; University of Notre Dame; Fiona Stanley Hospital; Pfizer; Johns Hopkins University; University of Queensland; Duke-NUS Medical School","keywords":"Medicine; Bacteremia; Daptomycin; Flucloxacillin; Vancomycin; Internal medicine; Randomized controlled trial; Clinical endpoint; Cefazolin; Intravenous therapy; Surgery; Antibiotics; Staphylococcus aureus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002888551,0.001081298,0.002575596,0.0004347229,0.0003446282,0.0008863794,0.0006942711,0.0016361,0.002317857],"category_scores_gemma":[0.005380874,0.0005328265,0.002843942,0.0003677385,0.0008486935,0.001089216,0.0005799455,0.001931481,0.0002350941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008375272,"about_ca_system_score_gemma":0.0009582736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006904862,"about_ca_topic_score_gemma":0.001675194,"domain_scores_codex":[0.9976351,0.001436121,0.0002461125,0.0003119925,0.0001352333,0.0002354733],"domain_scores_gemma":[0.9955164,0.001962718,0.001077853,0.0001869803,0.000179856,0.001076245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9682677,0.01052303,0.004029943,0.0004900486,0.001718691,0.00002621321,0.00003752192,0.000276897,0.0008242535,0.00003721856,0.0002019179,0.01356651],"study_design_scores_gemma":[0.48548,0.4874982,0.02197196,0.0001362639,0.002430418,0.00004175817,0.00007003114,0.001021598,0.0008055249,0.0001610762,0.00034946,0.00003373672],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957445,0.002736,0.0001217369,0.0001985573,0.0002212776,0.0004221542,0.0001209689,0.0000132099,0.0004215065],"genre_scores_gemma":[0.9971164,0.0008875487,0.0004733983,0.0002173648,0.0002338039,0.0006298904,0.0001478616,0.00000299228,0.000290591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002888551,"threshold_uncertainty_score":0.01527625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729142179709693,"score_gpt":0.2973649001022878,"score_spread":0.2800734783051909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}