{"id":"W3005971833","doi":"10.1016/j.cgh.2020.02.010","title":"Development and Validation of Clinical Scoring Tool to Predict Outcomes of Treatment With Vedolizumab in Patients With Ulcerative Colitis","year":2020,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Janssen Pharmaceuticals; Ferring Research Institute; University of California, San Diego; Genentech; Agency for Healthcare Research and Quality; Shire; National Institute of Diabetes and Digestive and Kidney Diseases; MedImmune; Kyowa Hakko Kirin; Arrien Pharmaceuticals; Western University; Covis Pharma; Eli and Edythe Broad Foundation; Crohn's and Colitis Foundation; School of Public Health, University of California Berkeley; Novo Nordisk; Vertex Pharmaceuticals; American College of Gastroenterology; F. Hoffmann-La Roche; Ironwood Pharmaceuticals, Incorporated; Prometheus; Takeda Pharmaceuticals U.S.A.; AbbVie; Johnson and Johnson; Teva Pharmaceutical Industries; Roche; GlaxoSmithKline; Merck; Seres Therapeutics; AstraZeneca; Eli Lilly and Company; Samsung; Bristol-Myers Squibb; Biogen; Pfizer; ActoGeniX; Boehringer Ingelheim; Amgen; Gilead Sciences; Celgene","keywords":"Vedolizumab; Medicine; Ulcerative colitis; Logistic regression; Cohort; Internal medicine; Receiver operating characteristic; Cohort study; Gastroenterology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000201436,0.0001413115,0.0005368229,0.00003109392,0.0000212038,0.000002395227,0.00006394087,0.0001397713,0.000004258609],"category_scores_gemma":[0.0001285746,0.0001055286,0.00004079448,0.00002612413,0.0003117069,0.000005247692,0.00008818456,0.00008559484,6.414748e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009263194,"about_ca_system_score_gemma":0.0001339892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004395036,"about_ca_topic_score_gemma":0.0002578108,"domain_scores_codex":[0.9983751,0.0002585008,0.0007443185,0.0003841976,0.00005660335,0.0001812616],"domain_scores_gemma":[0.9993645,0.00005536134,0.0002147134,0.0001336675,0.00008219414,0.0001495499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01857961,0.000258481,0.9789301,0.00002506759,0.0001972487,0.0000172212,0.0001195774,0.00001041982,0.00001127389,0.00002543075,0.000008833908,0.001816806],"study_design_scores_gemma":[0.006743067,0.01056211,0.9821192,0.00001559604,0.0000462114,0.000002766063,0.00003171546,0.00002253682,0.0002238951,0.000002686892,0.0001632829,0.00006689781],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999181,0.000005426649,0.0002193484,0.0001536533,0.00004231143,0.0003557769,0.00002435905,0.00000378815,0.00001430723],"genre_scores_gemma":[0.996976,0.00002154292,0.002322713,0.0005698158,0.00002402984,0.0000307371,0.0000424832,0.000009005675,0.000003705577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01183655,"threshold_uncertainty_score":0.430333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02660444224199663,"score_gpt":0.302973892684046,"score_spread":0.2763694504420494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}