{"id":"W3006053979","doi":"10.3390/biology9020030","title":"Genome-Scale Metabolic Reconstruction and in Silico Perturbation Analysis of the Polar Diatom Fragilariopsis cylindrus Predicts High Metabolic Robustness","year":2020,"lang":"en","type":"article","venue":"Biology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Biology; Robustness (evolution); Diatom; In silico; Systems biology; Metabolism; Biochemistry; Genetics; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635672,0.000141504,0.0003495105,0.0001284683,0.00004346726,0.000007474008,0.0001394471,0.0002182844,0.00001303649],"category_scores_gemma":[0.0001335612,0.0001079838,0.0001119279,0.0006681597,0.0001099681,0.0000058852,0.0000807023,0.0001118922,5.083933e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005238577,"about_ca_system_score_gemma":0.00002976465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001376595,"about_ca_topic_score_gemma":0.0001078785,"domain_scores_codex":[0.9989862,0.000131908,0.0002809072,0.0003841583,0.00005129502,0.0001655611],"domain_scores_gemma":[0.9995062,0.000005409692,0.0001265495,0.0002479886,0.00006055812,0.00005328936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004203454,0.00001995284,0.04382703,0.00001084649,0.0002383576,9.007134e-8,0.00009688245,0.003103192,0.9503788,0.00008371772,0.000003617464,0.002195497],"study_design_scores_gemma":[0.0004595434,0.00006409665,0.6786752,0.00000421458,0.0005916544,0.000009563702,0.00005247581,0.001707329,0.3110236,0.00001691612,0.007201131,0.0001942482],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928307,0.005172869,0.001040187,0.0004047756,0.0002742679,0.0001575986,0.00009097087,0.00001167489,0.00001693666],"genre_scores_gemma":[0.997788,0.00112045,0.0004898557,0.0001093528,0.0002980585,0.00001133936,0.0001452248,0.00001059198,0.00002709785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6393552,"threshold_uncertainty_score":0.4403451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005956713695211729,"score_gpt":0.1946988726226762,"score_spread":0.1887421589274645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}