{"id":"W3006055254","doi":"10.1158/1055-9965.epi-19-0891","title":"Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk","year":2020,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Ontario Institute for Cancer Research; Cancer Care Ontario","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; Conseil Régional des Pays de la Loire; U.S. Public Health Service; U.S. Department of Health and Human Services; DHHS Office of the Secretary; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Consejería de Educación, Junta de Castilla y León; Vetenskapsrådet; Medical Research Council; Swedish Cancer Foundation; Association Anne de Bretagne Genetique; Canadian Institutes of Health Research; California Department of Public Health; Matthias Lackas-Stiftung; Stockholms Läns Landsting; Division of Cancer Prevention, National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Moffitt Cancer Center; World Health Organization; Cancer Research UK; American Cancer Society; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; Canadian Cancer Society Research Institute; National Institutes of Health; Junta de Castilla y León","keywords":"Mendelian randomization; Colorectal cancer; Medicine; Internal medicine; Polyunsaturated fatty acid; Aspirin; Docosapentaenoic acid; Confounding; Eicosapentaenoic acid; Oncology; Genome-wide association study; Confidence interval; Lower risk; Cancer; Single-nucleotide polymorphism; Endocrinology; Biology; Genetics; Genotype; Fatty acid; Gene; Biochemistry; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01729443,0.0006914703,0.0009943973,0.001144148,0.0003789586,0.001170958,0.001065695,0.000807589,0.00399359],"category_scores_gemma":[0.05398886,0.000376411,0.001307179,0.001588915,0.001291392,0.0006073956,0.000772621,0.0008151772,0.000407283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006334999,"about_ca_system_score_gemma":0.00098658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002813611,"about_ca_topic_score_gemma":0.00150296,"domain_scores_codex":[0.9771816,0.01446349,0.001046652,0.00422332,0.002547737,0.0005373029],"domain_scores_gemma":[0.9762432,0.0136638,0.00317137,0.005855018,0.0008182952,0.0002482833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01272945,0.0004619375,0.709446,0.001147153,0.01413892,0.002365962,0.001055657,0.02259071,0.01755899,0.06633794,0.007793032,0.1443743],"study_design_scores_gemma":[0.003291489,0.005182887,0.6185218,0.0006269783,0.009834432,0.007200494,0.0005629247,0.1658927,0.01623051,0.1441848,0.02814708,0.0003239521],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6515988,0.002658056,0.3302571,0.001058586,0.0003726739,0.001528982,0.004203887,0.001523748,0.006798191],"genre_scores_gemma":[0.9609506,0.0003596985,0.03569308,0.0002507082,0.00003784492,0.0007871317,0.0008869884,0.00007288986,0.000961082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01729443,"threshold_uncertainty_score":0.09146273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03448742269432371,"score_gpt":0.3340795102670234,"score_spread":0.2995920875726997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}