{"id":"W3006090909","doi":"10.1007/s13346-020-00721-8","title":"Technological challenges in the preclinical development of an HIV nanovaccine candidate","year":2020,"lang":"en","type":"article","venue":"Drug Delivery and Translational Research","topic":"Biosensors and Analytical Detection","field":"Engineering","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Xunta de Galicia; Horizon 2020 Framework Programme; Ministerio de Educación, Cultura y Deporte","keywords":"Human immunodeficiency virus (HIV); Preclinical research; Computational biology; Biology; Virology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004575469,0.0004196165,0.0004539306,0.0005170935,0.0004803357,0.002386839,0.0008323071,0.001364141,0.002068572],"category_scores_gemma":[0.003779846,0.0004667773,0.0004526713,0.0002468873,0.0006592683,0.001369459,0.0007926316,0.001944578,0.001166016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006387262,"about_ca_system_score_gemma":0.001677154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006979184,"about_ca_topic_score_gemma":0.001588316,"domain_scores_codex":[0.9984604,0.0006630238,0.00008091594,0.000145357,0.000523541,0.000126706],"domain_scores_gemma":[0.9980657,0.001098401,0.0002170423,0.00009913624,0.0003759791,0.0001438863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004526779,0.0002353069,0.001319555,0.0009444214,0.00007793639,0.0005748574,0.0002647641,0.002338052,0.8919277,0.01167778,0.003561718,0.0866252],"study_design_scores_gemma":[0.00009965053,0.003807048,0.002349745,0.00030854,0.0001638584,0.003486705,0.0009402745,0.01616605,0.8287582,0.01087372,0.1329576,0.00008855421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4205548,0.09577303,0.4058976,0.04560827,0.00337205,0.001538128,0.001000323,0.000947473,0.02530834],"genre_scores_gemma":[0.7208135,0.0505379,0.2084393,0.005108676,0.0008193104,0.001058963,0.0006463416,0.0001555959,0.01242031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004575469,"threshold_uncertainty_score":0.0241977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1497990097846306,"score_gpt":0.3366769479830123,"score_spread":0.1868779381983818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}